Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 15/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 14/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.34 |
| ▸ | ITGAL | P20701 | 2/20 | 0.34 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4973096 | 0.84 | RBP4 (0.36) | ITGB1ITGA4ITGA5RBP4ITGB7 | |
| SCHEMBL3837009 | 0.81 | ITGA4 (0.47) | ITGB1ITGA4ITGA5ITGB7 | |
| SCHEMBL4210168 | 0.79 | ITGB1 (0.40) | ITGB1ITGA4ITGA5ITGB7ITGAV | |
| SCHEMBL4105639 | 0.74 | ITGB1 (0.52) | ITGB1ITGA4ITGA5ITGB7ITGAV | |
| SCHEMBL4218349 | 0.73 | ITGB1 (0.41) | ITGB1ITGA4ITGA5ITGB7ITGA2 | |
| SCHEMBL4094569 | 0.72 | ITGB1 (0.54) | ITGB1ITGA4ITGA5ITGB7ITGAV | |
| SCHEMBL3835954 | 0.67 | ITGA4 (0.47) | ITGB1ITGA4ITGA5ITGB7ITGAV | |
| SCHEMBL3832567 | 0.66 | ITGA4 (0.48) | ITGB1ITGA4ITGB7ITGAV | |
| SCHEMBL3835482 | 0.66 | ITGA4 (0.46) | ITGB1ITGA4ITGA5ITGB7 | |
| SCHEMBL3833939 | 0.65 | ITGA4 (0.47) | ITGB1ITGA4ITGA5ITGB7ITGA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957476-A1 | L-ALANINE DERIVATIVES | AstraZeneca AB (SE) | 2008-08-20 | — | — | EP | claimed |
| WO-2007060409-A1 | L-ALANINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-05-31 | — | — | WO | claimed |