Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | CA5A | P35218 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445417 | 1.00 | CA1 (0.56) | CA1CA2CA5ACA9HSD11B1 | |
| SCHEMBL669783 | 0.88 | CA1 (0.53) | CA1CA2CA5ACA9HSD11B1 | |
| SCHEMBL3145040 | 0.86 | CA2 (0.51) | CA1CA2CA5ACA9HSD11B1 | |
| SCHEMBL27171605 | 0.85 | CA1 (0.55) | CA1CA2CA5ACA9HSD11B1 | |
| SCHEMBL16046946 | 0.83 | CA1 (0.56) | CA1CA2CA5ACA9HSD11B1 | |
| SCHEMBL6050906 | 0.83 | CA1 (0.56) | CA1CA2CA5ACA9HSD11B1 | |
| SCHEMBL439543 | 0.82 | CA1 (0.60) | CA1CA2CA5ACA9HSD11B1 | |
| SCHEMBL16141195 | 0.80 | CA1 (0.58) | CA1CA2CA5ACA9HSD11B1 | |
| SCHEMBL4286706 | 0.79 | HSD11B1 (0.57) | CA1CA2CA5ACA9HSD11B1 | |
| SCHEMBL10185003 | 0.79 | HSD11B1 (0.57) | CA1CA2CA5ACA9HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971604-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | Amgen Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007048070-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC. (US) | 2007-04-26 | — | — | WO | disclosed |