Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29369520 | 1.00 | NOS3 (0.43) | NOS3NOS1NOS2TRPA1NPC1 | |
| SCHEMBL520026 | 0.86 | TSHR (0.44) | NOS3NOS1NOS2TRPA1NPC1 | |
| SCHEMBL12471274 | 0.85 | TSHR (0.48) | NOS3NOS1NOS2TRPA1NPC1 | |
| Propionaldehyde SCHEMBL28859775 | 0.84 | NOS3 (0.37) | NOS3NOS1NOS2TRPA1ALDH1A1 | |
| SCHEMBL28859774 | 0.82 | NOS3 (0.36) | NOS3NOS1NOS2TRPA1SMN1; SMN2 | |
| SCHEMBL30708207 | 0.77 | TRPA1 (0.39) | NOS3NOS1NOS2TRPA1NPC1 | |
| SCHEMBL30015193 | 0.77 | NOS3 (0.41) | NOS3NOS1NOS2TRPA1NPC1 | |
| SCHEMBL29861109 | 0.75 | — | — | |
| SCHEMBL60763 | 0.75 | — | — | |
| SCHEMBL14529115 | 0.74 | NOS3 (0.38) | NOS3NOS1NOS2TRPA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 505 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240262801-A1 | COMPOUNDS HAVING 5-(2-FLUORO-6-HYDROXYPHENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE AS INHIBITORS OF PROTEIN KINASE PHOSPHATASE ENZYMES | MONDEGO BIO, LDA. (PT) | 2024-08-08 | — | — | US | claimed |
| CN-114105089-A | Hydrogen storage material and preparation method thereof | 株洲铂陆新能源科技有限公司 | 2022-03-01 | — | — | CN | claimed |
| CN-108409518-B | Transition metal-free reductive cleavage of aromatic C-O, C-N and C-S bonds by reactive silanes | 加州理工学院 | 2021-10-12 | — | — | CN | claimed |
| CN-110156676-A | A kind of 3,4- dihydroquinoline -2 (1H) -one analog derivative and the preparation method and application thereof | 绍兴文理学院 | 2019-08-23 | — | — | CN | claimed |
| CN-110105277-A | Method for preparing 3, 4-dihydroquinoline-2 (1H) -ketone compound by using photocatalytic microchannel | 南京工业大学 | 2019-08-09 | — | — | CN | claimed |
| CN-106795156-B | 2- (morpholin-4-yl) -1, 7-naphthyridine | 拜耳制药股份公司 | 2019-07-30 | — | — | CN | claimed |
| CN-107987017-B | - 2 (1H)-quinolinones compound of a kind of 3,4-dihydro and the preparation method and application thereof | 绍兴文理学院 | 2019-07-12 | — | — | CN | claimed |
| CN-109836383-A | A method of preparing 3,4- dihydroquinoline -2 (1H) -one class compound | 安徽理工大学 | 2019-06-04 | — | — | CN | claimed |
| CN-109843379-A | Substituted ureas and methods of making and using the same | 梅比斯发现公司 | 2019-06-04 | — | — | CN | claimed |
| CN-109608457-A | A kind of drug and preparation method thereof for treating pneumonia | 牡丹江医学院 | 2019-04-12 | — | — | CN | claimed |
| WO-2014055586-A1 | TRANSITION-METAL FREE REDUCTIVE CLEAVAGE OF AROMATIC C-O, C-N, AND C-S BONDS BY ACTIVATED SILANES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-04-10 | — | — | WO | claimed |
| US-20100197670-A1 | AMIDINE, THIOUREA AND GUANIDINE DERIVATIVES OF 2-AMINOBENZOTHIAZOLES AND AMINOBENZOTHIAZINES FOR THEIR USE AS PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE PATHOLOGIES | ROTTAPHARM BIOTECH S.R.L. (IT) | 2010-08-05 | — | — | US | claimed |
| EP-2190829-A2 | AMIDINE, THIOUREA AND GUANIDINE DERIVATIVES OF 2-AMINOBENZOTHIAZOLES AND AMINOBENZOTHIAZINES FOR THEIR USE AS PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE PATHOLOGIES | Rottapharm S.p.A. (IT) | 2010-06-02 | — | — | EP | claimed |
| WO-2009040331-A2 | AMIDINE, THIOUREA AND GUANIDINE DERIVATIVES OF 2-AMINOBENZOTHIAZOLES AND AMINOBENZOTHIAZINES FOR THEIR USE AS PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE PATHOLOGIES | ROTTAPHARM S.P.A. (IT) | 2009-04-02 | — | — | WO | claimed |
| EP-1349536-B1 | STABLE SKIN CARE COMPOSITIONS CONTAINING A RETINOID AND A RETINOID BOOSTER SYSTEM | UNILEVER PLC (GB) | 2008-07-23 | — | — | EP | claimed |
| WO-2008033455-A2 | BIPHENYL AND HETEROARYL PHENYL DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASES INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | claimed |
| CN-1330291-C | Stable skin care compositions containing retinoids and retinoid booster systems | UNILEVER PLC (NL) | 2007-08-08 | — | — | CN | claimed |
| EP-0437105-B1 | Intermediates and colorants having primary hydroxyl enriched poly(oxyalkylene) moieties and their preparation | MILLIKEN RES CORP (US) | 1996-11-13 | — | — | EP | claimed |
| EP-0445926-B1 | Organic materials having sulfonamido linked poly(oxyalkylene) moieties and their preparation | MILLIKEN RES CORP (US) | 1996-08-21 | — | — | EP | claimed |
| EP-0566069-A1 | Tachykinin receptor antagonists, isoquinolones and their production | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-20 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240262801-A1 | COMPOUNDS HAVING 5-(2-FLUORO-6-HYDROXYPHENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE AS INHIBITORS OF PROTEIN KINASE PHOSPHATASE ENZYMES | PPM1A, TH, PPM1G | NOS3 1358/4885NOS1 695/4885NOS2 1096/4885 |
| US-20100197670-A1 | AMIDINE, THIOUREA AND GUANIDINE DERIVATIVES OF 2-AMINOBENZOTHIAZOLES AND AMINOBENZOTHIAZINES FOR THEIR USE AS PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE PATHOLOGIES | ABAT, SMN1; SMN2, IAPP | NOS3 204/4885NOS1 241/4885NOS2 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.