Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 7/20 | 0.48 |
| ▸ | CETP | P11597 | 5/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 7/20 | 0.39 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4976134 | 0.86 | FADS1 (0.57) | FADS1CETPGRM2 | |
| Ethylamine SCHEMBL4974176 | 0.85 | FADS1 (0.52) | FADS1CETPGRM2HTR2A | |
| SCHEMBL2896688 | 0.83 | GRM2 (0.49) | FADS1GRM2HTR2A | |
| SCHEMBL2901410 | 0.80 | FADS1 (0.49) | FADS1GRM2 | |
| SCHEMBL4977837 | 0.79 | FADS1 (0.58) | FADS1CETPGRM2HTR2A | |
| Ethylamine SCHEMBL2896685 | 0.72 | GRM2 (0.52) | FADS1GRM2HTR2A | |
| SCHEMBL2899915 | 0.72 | GRM2 (0.54) | FADS1GRM2HTR2A | |
| SCHEMBL2893979 | 0.72 | GRM2 (0.54) | FADS1GRM2HTR2A | |
| SCHEMBL2898909 | 0.72 | GRM2 (0.54) | FADS1GRM2HTR2A | |
| SCHEMBL2901407 | 0.70 | GRM2 (0.48) | FADS1GRM2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994016-A2 | 5-PHENYL-3-BENZYL-OXAZOLIDIN-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | claimed |
| WO-2007078523-A2 | 5-PHENYL-3-BENZYL-0XAZ0LIDIN-2-0NE DERIVATIVES AND RELATED COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | WO | claimed |