Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 8/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.43 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | HNF4A | P41235 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | BAD | Q92934 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylamine SCHEMBL4974176 | 0.95 | FADS1 (0.52) | FADS1GRM2PRSS12CETPSIRT1 | |
| SCHEMBL4977837 | 0.87 | FADS1 (0.58) | FADS1GRM2PRSS12CETP | |
| SCHEMBL2901410 | 0.86 | FADS1 (0.49) | FADS1GRM2 | |
| SCHEMBL4974178 | 0.86 | FADS1 (0.48) | FADS1GRM2CETP | |
| SCHEMBL2893979 | 0.81 | GRM2 (0.54) | FADS1GRM2PRSS12 | |
| SCHEMBL2898909 | 0.81 | GRM2 (0.54) | FADS1GRM2PRSS12 | |
| SCHEMBL2899915 | 0.81 | GRM2 (0.54) | FADS1GRM2PRSS12 | |
| Ethylamine SCHEMBL2896685 | 0.77 | GRM2 (0.52) | FADS1GRM2PRSS12 | |
| SCHEMBL2900121 | 0.76 | GRM2 (0.56) | FADS1GRM2 | |
| SCHEMBL4318364 | 0.74 | GRM2 (0.54) | FADS1GRM2PRSS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101426773-A | Metabotropic glutamate receptor potentiator 5-phenyl-3-benzyl-oxazolidin-2-one derivatives and related compounds for the treatment of psychiatric and neurological disorders | ASTRA AB (SE) | 2009-05-06 | — | — | CN | claimed |
| EP-1994016-A2 | 5-PHENYL-3-BENZYL-OXAZOLIDIN-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | claimed |
| WO-2007078523-A2 | 5-PHENYL-3-BENZYL-0XAZ0LIDIN-2-0NE DERIVATIVES AND RELATED COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | WO | claimed |