SCHEMBL497418

SCHEMBL497418

CC(C)(CCN)NC(=O)C(=O)NC(C)(C)CCN

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.32
ADRB3 P13945 1/20 0.32
FDPS P14324 1/20 0.32
PDE4D Q08499 1/20 0.32
PDE3A Q14432 1/20 0.32
NAALAD2 Q9Y3Q0 1/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27257381 0.88 ALDH1A1 (0.36) ALDH1A1
SCHEMBL3422991 0.84 ALDH1A1 (0.34) ALDH1A1LMNAADRB3FDPSPDE4D
SCHEMBL2343419 0.84 ALDH1A1 (0.40) ALDH1A1LMNAADRB3FDPSPDE4D
SCHEMBL3392434 0.82 ALDH1A1 (0.39) ALDH1A1LMNAADRB3FDPSPDE4D
SCHEMBL4088521 0.82 ALDH1A1 (0.39) ALDH1A1LMNAADRB3FDPSPDE4D
Hydrochloric Acid SCHEMBL17142804 0.80 KDM4E (0.38) ALDH1A1LMNAADRB3FDPSPDE4D
SCHEMBL8082769 0.78 ALDH1A1 (0.45) ALDH1A1KDM4E
SCHEMBL8082792 0.75 ALDH1A1 (0.34) ALDH1A1
SCHEMBL6262428 0.75 EPHX1 (0.42) ALDH1A1NAALAD2
SCHEMBL736116 0.75 MEN1 (0.53) ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1582549-B1 Flame retardant resin blends based on polymers derived from 2-hydrocarbyl-3,3-Bis(4-Hydroxyaryl)Phthalimidine monomers SABIC INNOVATIVE PLASTICS IP (NL) 2011-03-09 EP claimed
EP-1963399-B1 POLYCYCLIC DIHYDROXY COMPOUNDS AND METHODS FOR PREPARATION SABIC GLOBAL TECHNOLOGIES BV (NL) 2016-07-27 EP disclosed
EP-1805130-B1 METHOD FOR THE PREPARATION OF ALIPHATIC CHLOROFORMATES SABIC INNOVATIVE PLASTICS IP (NL) 2015-01-28 EP disclosed
US-8796399-B2 Polyethersulfone compositions with high heat and good impact resistance SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2014-08-05 US disclosed
EP-1805265-B1 METHOD FOR CONTROLLING HAZE IN AN ARTICLE COMPRISING A POLYMER COMPOSITION SABIC INNOVATIVE PLASTICS IP (NL) 2014-04-30 EP disclosed
US-8623971-B2 Polyethersulfone compositions with high heat and good impact resistance SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2014-01-07 US disclosed
US-20130245223-A1 HIGH HEAT POLYETHERSULFONE COMPOSITIONS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2013-09-19 US disclosed
US-8507590-B2 Fluorescent brighteners, methods of preparation thereof, fluorescent brightener compositions, and methods of preparation and uses thereof SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2013-08-13 US disclosed
EP-1581594-B1 POLYCARBONATE MOLDING COMPOSITIONS AND ARTICLES WITH IMPROVED SURFACE AESTHETICS SABIC INNOVATIVE PLASTICS IP (NL) 2013-03-27 EP disclosed
US-20120203001-A1 FLUORESCENT BRIGHTENERS, METHODS OF PREPARATION THEREOF, FLUORESCENT BRIGHTENER COMPOSITIONS, AND METHODS OF PREPARATION AND USES THEREOF SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-08-09 US disclosed
US-4351759-A OXIDATION RESISTANCE, OLEFIN POLYMERS CIBA-GEIGY CORPORATION (US) 1982-09-28 US disclosed
US-4318845-A STABILIZERS CIBA-GEIGY CORPORATION (US) 1982-03-09 US disclosed
US-4315848-A PROTECTIVE COATING FOR AUTOMOBILES CIBA-GEIGY CORPORATION (US) 1982-02-16 US disclosed
US-4288391-A STABILIZERS FOR POLYMERS AND LUBRICANTS CIBA-GEIGY CORPORATION (US) 1981-09-08 US disclosed
US-4283327-A USED AS A LIGHT STABILIZER CIBA-GEIGY CORPORATION (US) 1981-08-11 US disclosed
US-4278589-A 2-[2-Hydroxy-3,5-di-(α,α-dimethylbenzyl)phenyl]-2H-benzotriazole and stabilized compositions CIBA-GEIGY CORPORATION (US) 1981-07-14 US disclosed
US-4278590-A AUTOMOBILE FINISHES CIBA-GEIGY CORPORATION (US) 1981-07-14 US disclosed
US-4233207-A STABILIZING POLYMERS AGAINST OXIDATION, HEAT, AND RADIATION CIBA-GEIGY CORPORATION (US) 1980-11-11 US disclosed
US-4226763-A PHOTOSTABILIZERS HAVING GOOD HEAT RESISTANCE CIBA-GEIGY CORPORATION (US) 1980-10-07 US disclosed
US-4187074-A Water-soluble cationic oligourethane resins and the use thereof for the treatment of pelts or leather BAYER AKTIENGESELLSCHAFT (DE) 1980-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120203001-A1 FLUORESCENT BRIGHTENERS, METHODS OF PREPARATION THEREOF, FLUORESCENT BRIGHTENER COMPOSITIONS, AND METHODS OF PREPARATION AND USES THEREOF C1R, C1S, C9 ALDH1A1 2414/4885LMNA 388/4885ADRB3 610/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.