⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25227159 | 0.77 | — | — | |
| SCHEMBL7241013 | 0.75 | — | — | |
| SCHEMBL22175619 | 0.73 | — | — | |
| SCHEMBL31419277 | 0.73 | — | — | |
| SCHEMBL21404989 | 0.72 | — | — | |
| SCHEMBL22588401 | 0.65 | CALM1 (0.41) | — | |
| SCHEMBL25056456 | 0.64 | KEAP1 (0.35) | — | |
| SCHEMBL5063692 | 0.64 | HPGD (0.35) | — | |
| SCHEMBL25056463 | 0.62 | CYP4F2 (0.43) | — | |
| SCHEMBL22175729 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | Amgen, Inc (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084391-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B ( PKB) INHIBITORS | AMGEN INC. (US) | 2007-07-26 | — | — | WO | disclosed |