Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967601 | 0.84 | AQP1 (0.47) | — | |
| SCHEMBL4595488 | 0.80 | MAPK14 (0.42) | MAPK14DPP4ALDH1A1NPC1MAPT | |
| SCHEMBL4595485 | 0.79 | MAPK14 (0.41) | MAPK14CHRM5DPP4ALDH1A1NPC1 | |
| SCHEMBL4225377 | 0.78 | AQP1 (0.52) | MAPK14CHRM5DPP4TSHRLMNA | |
| SCHEMBL5605796 | 0.77 | MAPK14 (0.40) | MAPK14DPP4ALDH1A1NPC1MAPT | |
| SCHEMBL4226421 | 0.76 | AQP1 (0.56) | MAPK14ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL4226424 | 0.76 | AQP1 (0.42) | MAPK14CHRM5DPP4TSHRLMNA | |
| SCHEMBL4791163 | 0.76 | AQP1 (0.36) | — | |
| SCHEMBL5605793 | 0.75 | MAPK14 (0.41) | MAPK14DPP4ALDH1A1NPC1MAPT | |
| SCHEMBL5140813 | 0.74 | AQP1 (0.43) | MAPK14ALDH1A1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1898895-A2 | TREATMENT OF DRUG ABUSE | Wyeth (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006116148-A2 | (7-ARLYSUBSTITUTED 2, 3-DIHYDR0-1-BENZ0FURAN-2-YL) ALKYLAMINES IN THE TREATMENT' OF SUBSTANCE ABUSE | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |