Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 14/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972970 | 0.90 | MAPK14 (0.43) | GABRA5LMNA | |
| SCHEMBL4973225 | 0.89 | SMN1; SMN2 (0.44) | GABRA5GPBAR1LMNATP53MAPT | |
| SCHEMBL4972400 | 0.87 | GABRA5 (0.58) | GABRA5 | |
| SCHEMBL4973043 | 0.85 | HPGD (0.48) | GABRA5MAPT | |
| SCHEMBL4971884 | 0.85 | NPC1 (0.50) | GABRA5GPBAR1LMNATP53MAPT | |
| SCHEMBL4973050 | 0.85 | SMN1; SMN2 (0.51) | GABRA5LMNA | |
| SCHEMBL4970647 | 0.84 | ALDH1A1 (0.49) | GABRA5LMNATP53MAPT | |
| SCHEMBL4971020 | 0.84 | GABRA5 (0.55) | GABRA5 | |
| SCHEMBL4971834 | 0.83 | CD274 (0.50) | — | |
| SCHEMBL4971397 | 0.82 | GABRA5 (0.51) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968973-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | claimed |
| WO-2007074078-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-05 | — | — | WO | claimed |
| EP-1968973-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007074078-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-05 | — | — | WO | disclosed |