Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.38 |
| ▸ | ABAT | P80404 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004462 | 0.85 | ALDH1A1 (0.41) | ALDH1A1TSHRFDPSHPGDSMN1; SMN2 | |
| SCHEMBL6132027 | 0.81 | ALDH1A1 (0.70) | ALDH1A1TSHRFDPSHPGDSMN1; SMN2 | |
| SCHEMBL2714465 | 0.81 | ALDH1A1 (0.70) | ALDH1A1TSHRFDPSHPGDSMN1; SMN2 | |
| SCHEMBL9958281 | 0.79 | ALDH1A1 (0.72) | ALDH1A1TSHRFDPSHPGDSMN1; SMN2 | |
| SCHEMBL30049249 | 0.78 | ALDH1A1 (0.70) | ALDH1A1TSHRFDPSHPGDSMN1; SMN2 | |
| SCHEMBL18239636 | 0.78 | ALDH1A1 (0.70) | ALDH1A1TSHRFDPSHPGDSMN1; SMN2 | |
| SCHEMBL1748746 | 0.77 | ALDH1A1 (0.58) | ALDH1A1TSHRFDPSHPGDSMN1; SMN2 | |
| SCHEMBL12519223 | 0.76 | ALDH1A1 (0.47) | ALDH1A1TSHRFDPSHPGDMEN1 | |
| SCHEMBL2094282 | 0.76 | ALDH1A1 (0.47) | ALDH1A1TSHRFDPSHPGDAOX1 | |
| SCHEMBL5667158 | 0.74 | ALDH1A1 (0.64) | ALDH1A1TSHRFDPSHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1965785-A1 | COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR | N.V. Organon (NL) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071638-A1 | COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR | N.V. ORGANON (NL) | 2007-06-28 | — | — | WO | disclosed |