SCHEMBL497608

SCHEMBL497608

c1csc(C2CC2)c1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11286601 0.97
Methylamine SCHEMBL28610020 0.93 MAPT (0.46)
SCHEMBL498606 0.90 MAPT (0.47)
SCHEMBL8133890 0.90
SCHEMBL23108078 0.89 MAPT (0.47)
SCHEMBL4379122 0.89 ALDH1A1 (0.44)
SCHEMBL17729273 0.89 MAPT (0.43)
SCHEMBL12523733 0.89 MAPT (0.43)
SCHEMBL930295 0.87 MAPT (0.46)
SCHEMBL663162 0.87 MAPT (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 175 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119403798-A Novel compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof 东亚ST 株式会社 2025-02-07 CN claimed
CN-113316742-A Liquid crystal aligning agent, liquid crystal alignment film, liquid crystal display element, and novel monomer 日产化学株式会社 2021-08-27 CN claimed
CN-113272729-A Liquid crystal aligning agent, liquid crystal alignment film, and liquid crystal display element 日产化学株式会社 2021-08-17 CN claimed
US-20200388881-A1 SILICON-BASED ENERGY STORAGE DEVICES WITH FUNCTIONAL THIOPHENE COMPOUNDS OR DERIVATIVES OF THIOPHENE CONTAINING ELECTROLYTE ADDITIVES ENEVATE CORPORATION 2020-12-10 US claimed
CN-110062761-A Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and their use as GLUN2B receptor modulators 詹森药业有限公司 2019-07-26 CN claimed
CN-106995415-A It is used as the fusion benzo oxygen azepine * ketone of ion channel modulators 吉利德科学公司 2017-08-01 CN claimed
US-6515025-B2 Renin inhibitor PHARMACIA CORPORATION 2003-02-04 US claimed
US-20020025934-A1 Ethynyl alanine amino diol compounds for treatment of hypertension G.D. SEARLE & CO. (US) 2002-02-28 US claimed
US-6281235-B1 CONTROL OF HYPERTENSION. G.D. SEARLE & CO. 2001-08-28 US claimed
US-6174923-B1 ADMINISTERING ETHYNYL ALANINE AMINO DIOL COMPOUND FOR TREATING HYPERTENSION G. D. SEARLE & CO. 2001-01-16 US claimed
US-5849773-A Amino acyl amino propargyl diol compounds for treatment of hypertension G. D. SEARLE & CO. (US) 1998-12-15 US claimed
EP-0595328-B1 Process for production of 2-thiophene aldehydes SUMITOMO CHEMICAL CO (JP) 1996-07-10 EP claimed
US-5508295-A RENIN INHIBITORS G. D. SEARLE & CO. (US) 1996-04-16 US claimed
US-5484811-A ADMINISTERING A RENIN INHIBITOR TO A SUBJECT G. D. SEARLE & CO. (US) 1996-01-16 US claimed
EP-0610451-A1 ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION G.D. SEARLE & CO. (US) 1994-08-17 EP claimed
US-5330996-A Renin inhibitors G. D. SEARLE & CO. (US) 1994-07-19 US claimed
US-5227401-A ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION G. D. SEARLE & CO. (US) 1993-07-13 US claimed
WO-1993009108-A1 AMINO ACYL AMINO PROPARGYL DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION G.D. SEARLE & CO. (US) 1993-05-13 WO claimed
WO-1993009087-A1 ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION G.D. SEARLE & CO. (US) 1993-05-13 WO claimed
EP-0539976-A1 Ethynyl-alanine-amino-diol compounds for treatment of hypertension G.D. Searle & Co. (US) 1993-05-05 EP claimed