Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4978440 | 0.89 | LMNA (0.42) | HSP90AB1HSP90AA1PTPN11TLR4TLR9 | |
| SCHEMBL4980633 | 0.89 | HSP90AB1 (0.44) | HSP90AB1HSP90AA1PTPN11TLR4TLR9 | |
| SCHEMBL4976812 | 0.85 | LMNA (0.42) | HSP90AB1HSP90AA1TLR4TLR9TLR8 | |
| SCHEMBL4978027 | 0.83 | ALDH1A1 (0.53) | HSP90AB1HSP90AA1PTPN11MAPT | |
| SCHEMBL4980383 | 0.83 | RECQL (0.50) | HSP90AB1HSP90AA1PTPN11TLR4TLR9 | |
| SCHEMBL4980389 | 0.81 | HSP90AB1 (0.45) | HSP90AB1HSP90AA1PTPN11TLR4TLR9 | |
| SCHEMBL4974914 | 0.81 | MEN1 (0.50) | HSP90AB1HSP90AA1PTPN11HCRTR1HCRTR2 | |
| SCHEMBL4976359 | 0.81 | HSP90AB1 (0.52) | HSP90AB1PTPN11KDM2B | |
| SCHEMBL4977942 | 0.81 | KDM4E (0.53) | HSP90AB1HSP90AA1HCRTR1HCRTR2MAPT | |
| SCHEMBL4978438 | 0.81 | SIGLEC9 (0.40) | HSP90AB1HSP90AA1TLR4TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | HSP90AB1 2652/4885HSP90AA1 2689/4885PTPN11 4015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.