Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4994479 | 0.99 | KMT2A (0.36) | KMT2AGLAHSD11B1NPC1RAB9A | |
| Formic Acid SCHEMBL4976263 | 0.95 | HSD11B1 (0.34) | KMT2AGLAHSD11B1NPC1RAB9A | |
| Bicarbonate SCHEMBL5984921 | 0.89 | GLA (0.37) | KMT2AGLAHSD11B1NPC1RAB9A | |
| SCHEMBL5327618 | 0.88 | GLA (0.38) | KMT2AGLAHSD11B1NPC1RAB9A | |
| SCHEMBL5328510 | 0.88 | CYP3A4 (0.36) | KMT2AGLAHPGDCYP3A4CYP2C9 | |
| SCHEMBL5329533 | 0.84 | CYP3A4 (0.36) | KMT2AGLAHSD11B1NPC1RAB9A | |
| SCHEMBL5330704 | 0.84 | SMN1; SMN2 (0.43) | KMT2ANPC1RAB9AMEN1HPGD | |
| SCHEMBL5452650 | 0.83 | CTNNB1 (0.38) | KMT2ANPC1RAB9AMEN1HPGD | |
| SCHEMBL5451120 | 0.81 | PRKDC (0.34) | NPC1RAB9ACYP3A4CYP2C9P2RX7 | |
| SCHEMBL4977432 | 0.81 | PRKDC (0.34) | NPC1RAB9ACYP3A4CYP2C9P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326784-B2 | Intermediates for the preparation of tricyclic dihydropyrano-imidazo-pyridines derivatives | ALTANA PHARMA AG (DE) | 2008-02-05 | — | — | US | disclosed |
| US-20070117786-A1 | Intermediates for the preparation of tricyclic dihydropyrano-imidazo-pyridines derivatives | ALTANA PHARMA AG (DE) | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117786-A1 | Intermediates for the preparation of tricyclic dihydropyrano-imidazo-pyridines derivatives | CYP1A1, CYP3A4, CYP19A1 | KMT2A 3507/4885GLA 1522/4885HSD11B1 721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.