Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | WHR1 | P49842 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4963652 | 0.84 | FLT3 (0.49) | FLT3HRH4HRH3PDGFRBKIT | |
| Trifluoroacetic Acid SCHEMBL4963337 | 0.78 | FLT3 (0.52) | FLT3PDGFRBKIT | |
| SCHEMBL1095270 | 0.69 | EGFR (0.74) | FLT3EGFRERBB2 | |
| SCHEMBL1105423 | 0.69 | EGFR (0.74) | FLT3EGFRERBB2 | |
| Trifluoroacetic Acid SCHEMBL3882180 | 0.68 | FLT3 (0.54) | FLT3PDGFRBKIT | |
| Trifluoroacetic Acid SCHEMBL5525772 | 0.67 | ENPP1 (0.58) | — | |
| SCHEMBL4733568 | 0.67 | EGFR (0.71) | FLT3EGFRERBB2 | |
| SCHEMBL1105350 | 0.67 | EGFR (0.71) | FLT3EGFRERBB2 | |
| Trifluoroacetic Acid SCHEMBL18214922 | 0.66 | DPP4 (0.60) | HRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL15212493 | 0.66 | DPP4 (0.60) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896029-A1 | AMINOPYRIMIDINES AS KINASE MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006135644-A1 | AMINOPYRIMIDINES AS KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |