Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 4/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5528683 | 0.94 | ENPP1 (0.63) | ENPP1PDE3APDE3BMAPK1PDE10A | |
| SCHEMBL14599443 | 0.89 | ENPP1 (0.67) | ENPP1PDE3APDE3BPDE10AACHE | |
| Trifluoroacetic Acid SCHEMBL4965755 | 0.88 | ENPP1 (0.64) | ENPP1PDE3APDE3BMAPK1PDE10A | |
| Trifluoroacetic Acid SCHEMBL5075356 | 0.86 | ENPP1 (0.56) | ENPP1PDE3APDE3BMAPK1PDE10A | |
| Trifluoroacetic Acid SCHEMBL29589546 | 0.83 | ENPP1 (0.57) | ENPP1PDE3APDE3BMAPK1PDE10A | |
| Trifluoroacetic Acid SCHEMBL29589828 | 0.83 | ACHE (0.51) | ENPP1MAPK1PDE10AACHEBACE1 | |
| SCHEMBL7276406 | 0.82 | ENPP1 (0.73) | ENPP1PDE3APDE3BMAPK1PDE10A | |
| Trifluoroacetic Acid SCHEMBL29589036 | 0.82 | ACHE (0.52) | ENPP1PDE3APDE3BMAPK1PDE10A | |
| Trifluoroacetic Acid SCHEMBL29589021 | 0.82 | ENPP1 (0.67) | ENPP1MAPK1PDE10AACHEBACE1 | |
| Hydrochloric Acid SCHEMBL22441562 | 0.81 | ENPP1 (0.72) | ENPP1PDE3APDE3BMAPK1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
| US-20060281771-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281771-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | FLT3, CDC42BPG, PRKCQ | ENPP1 1922/4885PDE3A 3303/4885PDE3B 2347/4885 |
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | FLT3, BMX, ABL1 | ENPP1 2497/4885PDE3A 1892/4885PDE3B 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.