SCHEMBL497690

SCHEMBL497690

CC(C)N(C(C)C)C(C#N)COP

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8637513 0.78
SCHEMBL7906828 0.77
SCHEMBL8079312 0.76
SCHEMBL8191872 0.75 TSHR (0.32)
SCHEMBL6039265 0.74
SCHEMBL6854959 0.74
SCHEMBL10495860 0.74
SCHEMBL2564193 0.72 TSHR (0.33)
SCHEMBL7873516 0.71
SCHEMBL7122438 0.70 TSHR (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3739785-B2 2006-01-25 JP claimed
US-20040265802-A9 ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES FROEHLER BRIAN (US) 2004-12-30 US claimed
US-20030170680-A1 Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines FROEHLER BRIAN (US) 2003-09-11 US claimed
US-20030096980-A1 Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines ISIS PHARMACEUTICALS, INC. 2003-05-22 US claimed
US-6489466-B2 PRODUCING IMMOBILIZED OLIGONUCLEOTIDES ON A SUBSTRATE BY COVALENTLY ATTACHING A FIRST NUCLEOTIDE OR OLIGONUCLEOTIDE VIA A C-5' OXYGEN OF THE NUCLEOTIDE TO THE SUBSTRATE; C-3'OXYGEN PROTECTED WITH PHOTO- OR CHEMICAL-LABILE GROUPS LINDEN TECHNOLOGIES, INC. 2002-12-03 US claimed
EP-0637965-B1 ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES ISIS PHARMACEUTICALS INC (US) 2002-10-16 EP claimed
US-5792608-A Nuclease stable and binding competent oligomers and methods for their use GILEAD SCIENCES, INC. (US) 1998-08-11 US claimed
US-5645985-A USED FOR DIAGNOSIS TO DETECT VIRUSES OR DISEASED CONDITIONS GILEAD SCIENCES, INC. (US) 1997-07-08 US claimed
US-5594121-A DETECT VIRUSES, DISEASES GILEAD SCIENCES, INC. (US) 1997-01-14 US claimed
EP-0695306-A1 ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PURINES GILEAD SCIENCES, INC. (US) 1996-02-07 EP claimed
EP-0637965-A4 ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES. GILEAD SCIENCES INC (US) 1996-01-24 EP claimed
EP-0637965-A1 ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES GILEAD SCIENCES, INC. (US) 1995-02-15 EP claimed
EP-0616612-A4 NUCLEASE STABLE AND BINDING COMPETENT OLIGOMERS AND METHODS FOR THEIR USE. GILEAD SCIENCES INC (US) 1995-01-11 EP claimed
WO-1994024144-A2 ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PURINES GILEAD SCIENCES, INC. (US) 1994-10-27 WO claimed
EP-0616612-A1 NUCLEASE STABLE AND BINDING COMPETENT OLIGOMERS AND METHODS FOR THEIR USE GILEAD SCIENCES, INC. (US) 1994-09-28 EP claimed
WO-1993012135-A1 NUCLEASE STABLE AND BINDING COMPETENT OLIGOMERS AND METHODS FOR THEIR USE GILEAD SCIENCES, INC. (US) 1993-06-24 WO claimed
WO-1993010820-A1 ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES GILEAD SCIENCES, INC. (US) 1993-06-10 WO claimed
CN-116981676-A Cyano-protected riboguanosine phosphoramidites for reducing depyrimidition caused by alkylamine exposure during final deprotection 安捷伦科技有限公司 2023-10-31 CN disclosed
EP-0398391-A1 0,0'-Dicyanoethyl-phosphoramidites, a process for their preparation and their use in phosphorylation reactions CHIRON CORPORATION (US) 1990-11-22 EP disclosed
WO-1989009778-A1 OLIGONUCLEOTIDE CONTAINING 6-THIOGUANINE AT A PREDETERMINED SITE CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY (US) 1989-10-19 WO disclosed