SCHEMBL4976996

SCHEMBL4976996

Cn1nc(C(F)(F)F)c(OC(=O)Nc2ccccc2-c2ccc(C(F)(F)F)cc2)c1F

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 6/20 0.48
NTRK1 P04629 1/20 0.43
NPC1 O15118 1/20 0.42
TACR1 P25103 1/20 0.41
ABCG2 Q9UNQ0 6/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
RAB9A P51151 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
GAA P10253 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
HPGD P15428 1/20 0.39
CYP2C19 P33261 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
ABCB1 P08183 1/20 0.39
ALDH1A1 P00352 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4098297 0.82 MEN1 (0.52) CHRM3NTRK1TACR1ABCG2MEN1
SCHEMBL5139540 0.81 PDK1 (0.43) NPC1MEN1KMT2ARAB9ACYP1A2
SCHEMBL4976454 0.80 CHRM3 (0.49) CHRM3NTRK1NPC1TACR1ABCG2
SCHEMBL4685382 0.76 CHRM3 (0.47) CHRM3NTRK1NPC1TACR1ABCG2
SCHEMBL5139778 0.75 NPC1 (0.36) NPC1MEN1KMT2ARAB9ACYP1A2
SCHEMBL1085473 0.74 LMNA (0.48) TACR1MEN1KMT2ACYP1A2CYP3A4
SCHEMBL4850213 0.74 CHRM3 (0.47) CHRM3NTRK1NPC1TACR1ABCG2
SCHEMBL4683580 0.74 CHRM3 (0.49) CHRM3NTRK1NPC1TACR1ABCG2
SCHEMBL26633143 0.73 CHRM3 (0.48) CHRM3NTRK1NPC1RAB9ANPSR1
SCHEMBL4686169 0.73 CHRM3 (0.46) CHRM3NTRK1NPC1TACR1ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1903868-A1 FUNGICIDAL MIXTURES MADE FROM 1-METHYLPYRAZOL-4-YLCARBOXANILIDES BASF SE (DE) 2008-04-02 EP disclosed
WO-2007003644-A1 FUNGICIDAL MIXTURES MADE FROM 1-METHYLPYRAZOL-4-YLCARBOXANILIDES BASF AKTIENGESELLSCHAFT (DE) 2007-01-11 WO disclosed