Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884698 | 0.75 | KCNA5 (0.57) | ALDH1A1BRD9BRD7KCNA5RAB9A | |
| SCHEMBL1369604 | 0.74 | BRD9 (0.38) | ALDH1A1HPGDBRD9BRD7KCNA5 | |
| SCHEMBL4974371 | 0.74 | KCNA5 (0.50) | ALDH1A1HPGDKCNA5CYP11B1CYP11B2 | |
| SCHEMBL4975470 | 0.73 | KCNA5 (0.51) | ALDH1A1KCNA5CYP11B1CYP11B2TSHR | |
| SCHEMBL14536130 | 0.72 | BRD9 (0.52) | HPGDBRD9BRD7PDE10AMEN1 | |
| SCHEMBL4977357 | 0.72 | GPBAR1 (0.39) | CYP11B1CYP11B2CYP1A2CYP2C9 | |
| SCHEMBL4975732 | 0.67 | PPARA (0.34) | ALDH1A1KCNA5PDE10ATSHRATM | |
| SCHEMBL17276010 | 0.67 | BRD9 (0.56) | HPGDBRD9BRD7PDE10ARAB9A | |
| SCHEMBL31438401 | 0.67 | BRD9 (0.56) | HPGDBRD9BRD7PDE10ARAB9A | |
| SCHEMBL4979371 | 0.67 | HTR2A (0.44) | KCNA5CYP11B1CYP11B2GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |