Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.30 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4974371 | 0.77 | KCNA5 (0.50) | PTGS2ALDH1A1KCNA5KCNH2MAPT | |
| SCHEMBL4975470 | 0.76 | KCNA5 (0.51) | ALDH1A1PIM1KCNA5KCNN4KCNH2 | |
| SCHEMBL1367820 | 0.71 | F2RL1 (0.40) | PPARAPSMB5TDP1PTGS2F2RL1 | |
| SCHEMBL4977357 | 0.70 | GPBAR1 (0.39) | — | |
| SCHEMBL4979371 | 0.69 | HTR2A (0.44) | KCNA5KCNN4MAPTTSHRHTT | |
| SCHEMBL22738602 | 0.67 | PTGS2 (0.51) | PSMB5TDP1PTGS2FFAR2 | |
| SCHEMBL31538073 | 0.67 | PTGS2 (0.48) | PSMB5TDP1PTGS2F2RL1 | |
| SCHEMBL4977322 | 0.67 | ALDH1A1 (0.38) | ALDH1A1KCNA5KCNN4KCNH2TSHR | |
| SCHEMBL3623417 | 0.66 | PDK2 (0.42) | ALDH1A1PIM1KCNA5KCNH2L3MBTL1 | |
| SCHEMBL1366828 | 0.66 | L3MBTL1 (0.56) | ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | claimed |