Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4974371 | 0.77 | KCNA5 (0.50) | CYP11B1CYP11B2TSHRHTTKCNA5 | |
| SCHEMBL4975470 | 0.75 | KCNA5 (0.51) | CYP11B1CYP11B2CHRNA7TSHRHTT | |
| SCHEMBL1366828 | 0.73 | L3MBTL1 (0.56) | MAPK1 | |
| SCHEMBL18590701 | 0.73 | GAA (0.53) | GRM2GAATSHRKCNA5POLB | |
| SCHEMBL4979253 | 0.70 | CYP11B2 (0.46) | CYP11B1CYP11B2KCNA5 | |
| SCHEMBL4975773 | 0.70 | KCNA5 (0.39) | CYP11B1CYP11B2TSHRKCNA5POLB | |
| SCHEMBL4980305 | 0.70 | KCNA5 (0.39) | CYP11B1CYP11B2HTTKCNA5MAPK1 | |
| SCHEMBL1367309 | 0.70 | KCNA5 (0.44) | CYP11B1CYP11B2GRM2GAATSHR | |
| SCHEMBL4977357 | 0.70 | GPBAR1 (0.39) | CYP11B1CYP11B2HTR1ADRD2GRM2 | |
| SCHEMBL9129445 | 0.69 | CHRNA7 (0.57) | CHRNA7GAAKCNA5KCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | claimed |