Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PTPRA | P18433 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1792578 | 0.80 | PARP10 (0.49) | ADRA1DPARP10L3MBTL1RPS6KB1AURKA | |
| SCHEMBL29818128 | 0.75 | PARP10 (0.48) | ADRA1DPARP10L3MBTL1RPS6KB1AURKA | |
| SCHEMBL166483 | 0.75 | PARP10 (0.48) | ADRA1DPARP10L3MBTL1RPS6KB1AURKA | |
| SCHEMBL29394547 | 0.75 | AURKA (0.50) | ADRA1DPARP10L3MBTL1RPS6KB1AURKA | |
| SCHEMBL3644075 | 0.75 | AURKA (0.50) | ADRA1DPARP10L3MBTL1RPS6KB1AURKA | |
| SCHEMBL31659786 | 0.74 | ADRA1D (0.47) | ADRA1DPARP10L3MBTL1RPS6KB1AURKA | |
| SCHEMBL6378764 | 0.74 | ADRA1D (0.47) | ADRA1DPARP10L3MBTL1RPS6KB1AURKA | |
| SCHEMBL6093499 | 0.73 | AURKA (0.46) | ADRA1DPARP10L3MBTL1RPS6KB1AURKA | |
| SCHEMBL14917467 | 0.73 | PARP1 (0.57) | IKBKBPARP1 | |
| SCHEMBL28310422 | 0.72 | PARP10 (0.52) | ADRA1DPARP10L3MBTL1RPS6KB1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971604-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | Amgen Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007048070-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC. (US) | 2007-04-26 | — | — | WO | disclosed |