Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 4/20 | 0.65 |
| ▸ | PHF8 | Q9UPP1 | 4/20 | 0.65 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.65 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.65 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | KDM4A | O75164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31454264 | 1.00 | KDM5A (0.65) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL11848931 | 1.00 | KDM5A (0.65) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL1456488 | 1.00 | KDM5A (0.65) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL1457469 | 1.00 | KDM5A (0.65) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL4449247 | 1.00 | KDM5A (0.65) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL11851432 | 1.00 | KDM5A (0.65) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL16046794 | 1.00 | KDM5A (0.65) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL826408 | 1.00 | KDM5A (0.65) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL11849540 | 1.00 | KDM5A (0.65) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL28448757 | 1.00 | KDM5A (0.65) | KDM5APHF8KDM2AKDM4CKDM7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541362-B2 | Cyclopropyl compounds and compositions for delivering active agents | EMISPHERE TECHNOLOGIES, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541362-B2 | Cyclopropyl compounds and compositions for delivering active agents | EMISPHERE TECHNOLOGIES, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| WO-2013116126-A1 | NOVEL LOW MOLECULAR WEIGHT, BIODEGRADABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | MERCK SHARP & DOHME CORP. (US) | 2013-08-08 | — | — | WO | disclosed |
| US-20090220451-A1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090220451-A1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| US-7339065-B2 | Design and synthesis of optimized ligands for PPAR | BETHESDA PHARMACEUTICALS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-20070099969-A1 | Design and synthesis of optimized ligands for ppar | THE UNIVERSITY OF MISSISSIPPI | 2007-05-03 | — | — | US | disclosed |
| WO-2007022532-A2 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
| WO-2002076177-A2 | DESIGN AND SYNTHESIS OF OPTIMIZED LIGANDS FOR PPAR | BETHESDA PHARMACEUTICALS, INC. (US) | 2002-10-03 | — | — | WO | disclosed |
| US-3993773-A | Control of mites with esters of cyclopropane substituted carboxylic acids | ZOECON CORPORATION (US) | 1976-11-23 | — | — | US | disclosed |
| US-3960907-A | MITICIDES | ZOECON CORPORATION (US) | 1976-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090220451-A1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | PAICS, ABCB4, ABCB11 | KDM5A 4407/4885PHF8 4057/4885KDM2A 4542/4885 |
| US-20070099969-A1 | Design and synthesis of optimized ligands for ppar | PPARD, PPARA, PPARG | KDM5A 172/4885PHF8 1250/4885KDM2A 679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.