Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.35 |
| ▸ | HTR6 | P50406 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985604 | 0.79 | HTR1A (0.41) | HTR6HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3493619 | 0.71 | CA1 (0.44) | JAK2HTR1AHTR7SLC6A4SLC6A2 | |
| SCHEMBL3491841 | 0.70 | HCRTR1 (0.47) | SLC6A4SLC6A2SLC6A3KIF11EZH2 | |
| SCHEMBL8238486 | 0.70 | HCRTR1 (0.47) | NOTUMSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3495194 | 0.69 | CA1 (0.43) | JAK2HTR1AHTR7SLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL3495897 | 0.69 | HCRTR1 (0.47) | NOTUMSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5171411 | 0.69 | CA1 (0.43) | JAK2HTR1AHTR7SLC6A4SLC6A2 | |
| SCHEMBL8238469 | 0.69 | NOTUM (0.52) | NOTUMSIGMAR1ALDH1A1 | |
| SCHEMBL8236184 | 0.66 | HCRTR1 (0.53) | NOTUMSLC6A4SLC6A2SLC6A3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3494081 | 0.66 | HCRTR1 (0.52) | NOTUMSLC6A4SLC6A2SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |