Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 3/20 | 0.35 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4978491 | 0.79 | NOTUM (0.35) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL3491561 | 0.78 | PTGER1 (0.48) | AVPR2AVPR1APTGER1DHODH | |
| SCHEMBL8238361 | 0.77 | MAPT (0.48) | AVPR2AVPR1APTGER1DHODH | |
| SCHEMBL3493942 | 0.74 | TSHR (0.47) | PTGER1 | |
| SCHEMBL3493642 | 0.71 | CA1 (0.45) | HIF1AAVPR2AVPR1APTGER1 | |
| Hydrochloric Acid SCHEMBL3495368 | 0.69 | HCRTR1 (0.46) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27573516 | 0.68 | L3MBTL1 (0.43) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3492269 | 0.66 | HCRTR1 (0.47) | SLC6A2SLC6A4SLC6A3HIF1A | |
| SCHEMBL8238469 | 0.65 | NOTUM (0.52) | — | |
| SCHEMBL4321471 | 0.65 | STS (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |