Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723659 | 0.77 | KDM1A (0.45) | MAPTKDM4EALDH1A1HPGDKDM1A | |
| SCHEMBL3173617 | 0.76 | HTR2C (0.41) | HTR2AHTR2CHTR2BADRA1ATSHR | |
| SCHEMBL4779844 | 0.76 | ALDH1A1 (0.33) | MAPTSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL894904 | 0.74 | TAAR1 (0.43) | TAAR1HTR2CMAOBMAPTMAOA | |
| SCHEMBL2317406 | 0.73 | HTR2C (0.40) | TAAR1HTR2CHTR2BKDM1A | |
| SCHEMBL4718986 | 0.73 | KDM1A (0.32) | KDM4EALDH1A1KDM1A | |
| SCHEMBL1849372 | 0.73 | TAAR1 (0.45) | TAAR1DPP4HTR2AHTR2CHTR2B | |
| SCHEMBL8646652 | 0.71 | TAAR1 (0.44) | TAAR1DPP4HTR2AHTR2CHTR2B | |
| SCHEMBL5537151 | 0.71 | TAAR1 (0.46) | TAAR1MAOBALDH1A1TNKS2KDM1A | |
| SCHEMBL3153886 | 0.70 | TAAR1 (0.42) | TAAR1DPP4HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991540-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007098214-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-08-30 | — | — | WO | disclosed |