Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 8/20 | 0.34 |
| ▸ | MAOA | P21397 | 7/20 | 0.34 |
| ▸ | KDM1A | O60341 | 5/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7061062 | 0.82 | CYP1A2 (0.32) | MAPTCYP2C19CYP1A2 | |
| SCHEMBL4972612 | 0.81 | KDM1A (0.32) | MAPTKDM1AHTR2CRAB9A | |
| SCHEMBL5537151 | 0.81 | TAAR1 (0.46) | TAAR1MAOBKDM1ASLC6A2SLC6A3 | |
| SCHEMBL4972144 | 0.81 | KDM1A (0.38) | KDM1ALMNASLC6A2HTR2CSLC6A3 | |
| SCHEMBL4971045 | 0.80 | CYP2A6 (0.46) | TSHRCYP2C19CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7353488 | 0.79 | TAAR1 (0.51) | TAAR1TSHRMAPTMAOBMAOA | |
| SCHEMBL4979245 | 0.74 | TAAR1 (0.49) | TAAR1TSHRMAPTMAOBMAOA | |
| SCHEMBL4723659 | 0.72 | KDM1A (0.45) | MAPTKDM1ASLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL3637659 | 0.72 | NOS3 (0.39) | MAPTHSD17B10ALDH1A1 | |
| SCHEMBL4779844 | 0.71 | ALDH1A1 (0.33) | MAPTLMNAHSD17B10ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067931-B2 | 2-heteroaryl carboxamides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-06-30 | — | — | US | claimed |
| US-20140350008-A1 | 2-HETEROARYL CARBOXAMIDES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-11-27 | — | — | US | claimed |
| US-20110263591-A1 | 2-HETEROARYL CARBOXAMIDES | BAYER SCHERING PHARMA AG (DE) | 2011-10-27 | — | — | US | claimed |
| US-7977485-B2 | 2-heteroaryl carboxamides | BAYER SCHERING PHARMA AKTIENGESELLSHAFT (DE) | 2011-07-12 | — | — | US | claimed |
| US-6743788-B2 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASE; AUTOIMMUNE DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-06-01 | — | — | US | claimed |
| US-20040067945-A1 | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2004-04-08 | — | — | US | claimed |
| US-20030186978-A1 | Novel telomerase inhibitors | PHARMACIA ITALIA, SPA (IT) | 2003-10-02 | — | — | US | claimed |
| WO-2001096339-A1 | NOVEL TELOMERASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-20 | — | — | WO | claimed |
| WO-2024148184-A1 | COMPOUNDS AND PROCESSES FOR THE PREPARATION OF JAK INHIBITORS | AERIE PHARMACEUTICALS, INC. (US) | 2024-07-11 | — | — | WO | disclosed |
| EP-4363058-A1 | AZETIDINYL PYRIMIDINES AND USES THEREOF | Aerie Pharmaceuticals, Inc. (US) | 2024-05-08 | — | — | EP | disclosed |
| CN-117642395-A | Azetidinyl pyrimidines and their use | 爱瑞制药公司 | 2024-03-01 | — | — | CN | disclosed |
| WO-2024006916-A1 | AZETIDINYL PYRIMIDINES AND USES THEREOF AS JAK INHIBITORS | AERIE PHARMACEUTICALS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |
| US-20240002392-A1 | Azetidinyl Pyrimidines and Uses Thereof | ALCON INC. (CH) | 2024-01-04 | — | — | US | disclosed |
| WO-2023279105-A1 | AZETIDINYL PYRIMIDINES AND USES THEREOF | AERIE PHARMACEUTICALS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |
| EP-0602209-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |
| EP-0236140-A2 | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240002392-A1 | Azetidinyl Pyrimidines and Uses Thereof | JAK2, JAK1, JAK3 | TAAR1 4049/4885TSHR 3330/4885MAPT 4314/4885 |
| US-20140350008-A1 | 2-HETEROARYL CARBOXAMIDES | GRIN2A, CNR2, GRIN2C | TAAR1 451/4885TSHR 4355/4885MAPT 647/4885 |
| US-20030186978-A1 | Novel telomerase inhibitors | TERT, TERF2IP, TERF2 | TAAR1 3797/4885TSHR 2517/4885MAPT 2080/4885 |
| US-20040067945-A1 | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors | PDE3B, PDE3A, PDE2A | TAAR1 1454/4885TSHR 3349/4885MAPT 2747/4885 |
| US-20110263591-A1 | 2-HETEROARYL CARBOXAMIDES | GRIN2A, CNR2, GRIN2C | TAAR1 451/4885TSHR 4355/4885MAPT 647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.