Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL3703143 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL3703148 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL4231762 | 0.93 | TSHR (0.43) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL4231763 | 0.93 | TSHR (0.43) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| SCHEMBL2536499 | 0.91 | — | — | |
| SCHEMBL9335555 | 0.88 | ALDH1A1 (0.53) | TSHREGLN1ALDH1A1ALOX15CYP2D6 | |
| SCHEMBL10553508 | 0.88 | ALDH1A1 (0.53) | TSHREGLN1ALDH1A1ALOX15CYP2D6 | |
| Hydrogen Peroxide SCHEMBL27498555 | 0.88 | — | — | |
| SCHEMBL10554896 | 0.88 | ALDH1A1 (0.53) | TSHREGLN1ALDH1A1ALOX15CYP2D6 | |
| SCHEMBL23108 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106867679-A | A kind of sorbent regeneration process of the plant transformer oil of deterioration | 国家电网公司 | 2017-06-20 | — | — | CN | claimed |
| CN-106244306-A | A kind of vegetable insulating oil based on amygdalus pedunculata pall oil and application thereof | 广东卓原新材料科技有限公司 | 2016-12-21 | — | — | CN | claimed |
| CN-106190431-A | A kind of vegetable insulating oil based on almond oil and application thereof | 广东卓原新材料科技有限公司 | 2016-12-07 | — | — | CN | claimed |
| CN-110437900-A | A kind of surfactant compound pour-point depressant and its preparation method and application | SHANGHAI INST TECH | 2019-11-12 | — | — | CN | disclosed |
| CN-104388056-B | A kind of high preparation process and application method for leading conduction oil | 山东华安新材料有限公司 | 2018-05-18 | — | — | CN | disclosed |
| CN-106867679-A | A kind of sorbent regeneration process of the plant transformer oil of deterioration | 国家电网公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-106244306-A | A kind of vegetable insulating oil based on amygdalus pedunculata pall oil and application thereof | 广东卓原新材料科技有限公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-106190431-A | A kind of vegetable insulating oil based on almond oil and application thereof | 广东卓原新材料科技有限公司 | 2016-12-07 | — | — | CN | disclosed |
| EP-1991643-A2 | USE OF POLYNUCLEAR PHENOLIC COMPOUNDS AS STABILISERS | BASF SE (DE) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007099048-A2 | USE OF POLYNUCLEAR PHENOLIC COMPOUNDS AS STABILISERS | BASF SE (DE) | 2007-09-07 | — | — | WO | disclosed |
| CN-1518588-A | Carboxylate-vinyl ester copolymer blend compositions for lubricant flow improvement | 英菲诺姆国际有限公司 | 2004-08-04 | — | — | CN | disclosed |
| EP-1385927-A1 | CARBOXYLATE-VINYL ESTER COPOLYMER, BLEND COMPOSITIONS FOR LUBRICATING OIL FLOW IMPROVEMENT | Infineum International Limited (GB) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002088283-A1 | CARBOXYLATE-VINYL ESTER COPOLYMER, BLEND COMPOSITIONS FOR LUBRICATING OIL FLOW IMPROVEMENT | INFINEUM INTERNATIONAL LIMITED (GB) | 2002-11-07 | — | — | WO | disclosed |
| US-6475963-B1 | Carboxylate-vinyl ester copolymer blend compositions for lubricating oil flow improvement | INFINEUM INTERNATIONAL LTD. (GB) | 2002-11-05 | — | — | US | disclosed |