Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.68 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4978532 | 0.93 | HSP90AB1 (0.68) | HSP90AB1HSP90AA1KDM2BLMNAMAPT | |
| SCHEMBL4981538 | 0.91 | HSP90AB1 (0.55) | HSP90AB1HSP90AA1KDM2BLDHAHRH3 | |
| SCHEMBL4979037 | 0.91 | HSP90AB1 (0.55) | HSP90AB1HSP90AA1ALDH1A1KDM4ENPC1 | |
| SCHEMBL4980700 | 0.89 | KDM4E (0.56) | HSP90AB1HSP90AA1ALDH1A1HTTKDM4E | |
| SCHEMBL4975968 | 0.87 | HSP90AB1 (0.51) | HSP90AB1HSP90AA1ALDH1A1LMNAKDM4E | |
| SCHEMBL4980394 | 0.87 | KDM2B (0.55) | HSP90AB1KDM2BKDM4EHRH3USP2 | |
| SCHEMBL4980664 | 0.86 | KDM4E (0.55) | HSP90AB1ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL4978525 | 0.86 | HSP90AB1 (0.52) | HSP90AB1KDM2BALDH1A1KDM4EMAPT | |
| SCHEMBL4976020 | 0.86 | HSP90AB1 (0.57) | HSP90AB1KDM2BALDH1A1LMNAHTT | |
| SCHEMBL4982016 | 0.86 | HSP90AB1 (0.55) | HSP90AB1HSP90AA1ALDH1A1KDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | HSP90AB1 2652/4885HSP90AA1 2689/4885KDM2B 1937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.