Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4978041 | 0.92 | GAA (0.51) | KDM4EHSP90AB1ALDH1A1HTTHCRTR1 | |
| SCHEMBL4978905 | 0.91 | LMNA (0.47) | KDM4EHSP90AB1HTTHCRTR1HCRTR2 | |
| SCHEMBL4975077 | 0.91 | HSP90AB1 (0.49) | KDM4EHSP90AB1ALDH1A1HSD17B10HTT | |
| SCHEMBL4973674 | 0.90 | HSP90AB1 (0.48) | KDM4EHSP90AB1ALDH1A1HSD17B10HCRTR1 | |
| SCHEMBL4978109 | 0.90 | HSP90AB1 (0.46) | KDM4EHSP90AB1ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL4976769 | 0.90 | TSHR (0.48) | KDM4EHSP90AB1ALDH1A1HSD17B10HCRTR1 | |
| SCHEMBL4976400 | 0.89 | HSP90AB1 (0.47) | KDM4EHSP90AB1ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL4979839 | 0.89 | HSP90AB1 (0.68) | KDM4EHSP90AB1ALDH1A1HSD17B10HTT | |
| SCHEMBL4978532 | 0.89 | HSP90AB1 (0.68) | HSP90AB1HCRTR1HCRTR2HSP90AA1 | |
| SCHEMBL4980604 | 0.89 | HSP90AB1 (0.44) | KDM4EHSP90AB1HCRTR1HCRTR2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | KDM4E 1865/4885HSP90AB1 2652/4885ALDH1A1 1142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.