Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4976968 | 0.93 | HSP90AB1 (0.49) | HSP90AB1TP53MAPTLMNAHSP90AA1 | |
| SCHEMBL4978041 | 0.92 | GAA (0.51) | HSP90AB1ALDH1A1LMNAHSP90AA1GAA | |
| SCHEMBL4980700 | 0.88 | KDM4E (0.56) | HSP90AB1ALDH1A1HSP90AA1KDM4E | |
| SCHEMBL4979839 | 0.87 | HSP90AB1 (0.68) | HSP90AB1ALDH1A1MAPTLMNAHSP90AA1 | |
| SCHEMBL4978532 | 0.87 | HSP90AB1 (0.68) | HSP90AB1MAPTLMNAHSP90AA1 | |
| SCHEMBL4978645 | 0.86 | HSP90AB1 (0.46) | HSP90AB1ALDH1A1TP53MAPTLMNA | |
| SCHEMBL4979037 | 0.86 | HSP90AB1 (0.55) | HSP90AB1ALDH1A1HSP90AA1KDM4E | |
| SCHEMBL4982016 | 0.86 | HSP90AB1 (0.55) | HSP90AB1ALDH1A1HSP90AA1KDM4E | |
| SCHEMBL4979696 | 0.86 | KDM4E (0.52) | HSP90AB1ALDH1A1MAPTGAAKDM4E | |
| SCHEMBL4975077 | 0.86 | HSP90AB1 (0.49) | HSP90AB1ALDH1A1MAPTHSP90AA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | HSP90AB1 2652/4885ALDH1A1 1142/4885L3MBTL1 2549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.