Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.55 |
| ▸ | JAK2 | O60674 | 14/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | GRK4 | P32298 | 1/20 | 0.49 |
| ▸ | GRK5 | P34947 | 1/20 | 0.49 |
| ▸ | GRK6 | P43250 | 1/20 | 0.49 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.49 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL588783 | 0.85 | JAK3 (0.57) | JAK3JAK2NTRK1AURKAIGF1R | |
| SCHEMBL3034183 | 0.84 | NTRK1 (0.71) | JAK3JAK2NTRK1AURKAIGF1R | |
| SCHEMBL3950465 | 0.81 | NTRK1 (0.53) | JAK3JAK2NTRK1AURKAIGF1R | |
| SCHEMBL589659 | 0.81 | NTRK1 (0.56) | JAK3JAK2NTRK1AURKAIGF1R | |
| SCHEMBL4978955 | 0.79 | JAK3 (0.57) | JAK3JAK2NTRK1AURKAIGF1R | |
| SCHEMBL4981488 | 0.77 | IGF1R (0.34) | JAK3JAK2NTRK1AURKAIGF1R | |
| SCHEMBL588730 | 0.76 | NTRK1 (0.73) | JAK3JAK2NTRK1AURKAIGF1R | |
| SCHEMBL31060183 | 0.76 | NTRK1 (0.73) | JAK3JAK2NTRK1AURKAIGF1R | |
| SCHEMBL29434985 | 0.76 | NTRK1 (0.73) | JAK3JAK2NTRK1AURKAIGF1R | |
| SCHEMBL18281508 | 0.76 | NTRK1 (0.73) | JAK3JAK2NTRK1AURKAIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |