Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15690371 | 0.88 | GPR119 (0.64) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL15315327 | 0.77 | GPR119 (0.80) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL4557583 | 0.76 | GPR119 (0.72) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL29444725 | 0.76 | GPR119 (1.00) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL114213 | 0.76 | GPR119 (1.00) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL14695802 | 0.76 | GPR119 (0.54) | GPR119CYP3A4CYP2C19KCNH2 | |
| SCHEMBL2734562 | 0.73 | GPR119 (0.89) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL514572 | 0.73 | GPR119 (0.66) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL14968406 | 0.72 | GPR119 (0.81) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL19434252 | 0.71 | GPR119 (0.55) | GPR119CYP3A4CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971862-A2 | METHODS OF USING GPR119 RECEPTOR TO IDENTIFY COMPOUNDS USEFUL FOR INCREASING BONE MASS IN AN INDIVIDUAL | Arena Pharmaceuticals, Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007120689-A2 | METHODS OF USING GPR119 RECEPTOR TO IDENTIFY COMPOUNDS USEFUL FOR INCREASING BONE MASS IN AN INDIVIDUAL | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |