Sugi Predict

Sugi Predict / Compounds / SCHEMBL4980225

SCHEMBL4980225

SCHEMBL4980225

Cc1c(N)[nH]c2ccccc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AHR P35869 2/20 0.61
▸ ALDH1A1 P00352 4/20 0.50
▸ HSD17B10 Q99714 2/20 0.50
▸ DAO P14920 1/20 0.50
▸ DDO Q99489 1/20 0.50
▸ GPR3 P46089 1/20 0.50
▸ MAPT P10636 2/20 0.46
▸ CYP3A4 P08684 1/20 0.46
▸ KIF11 P52732 2/20 0.45
▸ CYP1A2 P05177 2/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ TNKS2 Q9H2K2 1/20 0.45
▸ CYP11B1 P15538 1/20 0.44
▸ CYP11B2 P19099 1/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ HTT P42858 3/20 0.44
▸ TSHR P16473 1/20 0.44
▸ GAA P10253 2/20 0.44
▸ HPGD P15428 2/20 0.44
▸ RXFP1 Q9HBX9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30740647 1.00 AHR (0.61) AHRALDH1A1HSD17B10DAODDO
SCHEMBL7195762 0.78 AHR (0.70) AHRALDH1A1HSD17B10DAODDO
SCHEMBL154593 0.76 AHR (1.00) AHRALDH1A1HSD17B10DAODDO
SCHEMBL29420757 0.76 AHR (1.00) AHRALDH1A1HSD17B10DAODDO
SCHEMBL29366882 0.76 ALDH1A1 (0.55) AHRALDH1A1HSD17B10GPR3MAPT
SCHEMBL8598229 0.76 ALDH1A1 (0.55) AHRALDH1A1HSD17B10GPR3MAPT
SCHEMBL13847310 0.75 DAO (0.62) AHRALDH1A1HSD17B10DAODDO
SCHEMBL8087766 0.74 AHR (0.57) AHRALDH1A1HSD17B10DAODDO
SCHEMBL4741007 0.73 AHR (0.61) AHRALDH1A1HSD17B10DAODDO
SCHEMBL6817362 0.73 AHR (0.61) AHRALDH1A1HSD17B10DAODDO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100548979-C A kind of method of synthetic 3-methyl amino indole compound SHANGHAI INST ORGANIC CHEM (CN) 2009-10-14 — — CN claimed
EP-1978805-A1 PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2008-10-15 — — EP claimed
WO-2007085660-A1 PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2007-08-02 — — WO claimed
CN-100999490-A Process of synthesizing 3-methyl amino indole compound SHANGHAI INST OF ORGANIST CHEM (CN) 2007-07-18 — — CN claimed
US-20230312481-A1 SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF ARBUTUS BIOPHARMA CORP (CA) 2023-10-05 — — US disclosed
CN-107011239-A A kind of synthetic method of pharmaceutical intermediate aryl substituted indole compound 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 2017-08-04 — — CN disclosed
CN-106957253-A A kind of synthetic method of the aryl-indole compounds of medicine intermediate 2 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 2017-07-18 — — CN disclosed
CN-106866489-A A kind of synthetic method of nitrogenous pharmaceutical intermediate indole derivatives 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 2017-06-20 — — CN disclosed
CN-100548979-C A kind of method of synthetic 3-methyl amino indole compound SHANGHAI INST ORGANIC CHEM (CN) 2009-10-14 — — CN disclosed
CN-100548979-C A kind of method of synthetic 3-methyl amino indole compound SHANGHAI INST ORGANIC CHEM (CN) 2009-10-14 — — CN disclosed
CN-100548979-C A kind of method of synthetic 3-methyl amino indole compound SHANGHAI INST ORGANIC CHEM (CN) 2009-10-14 — — CN disclosed
EP-1978805-A1 PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2008-10-15 — — EP disclosed
EP-0635269-A1 Use of N-(Pyridinyl)-1H-Indol-1-Amines for the preparation of a medicament for the treatment of obsessive-compulsive disorders HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1995-01-25 — — EP disclosed
EP-0287982-B1 N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments HOECHST ROUSSEL PHARMA (US) 1994-12-07 — — EP disclosed
US-5039811-A Analgesics, antidepressants, memory activators; condensation, reduction HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1991-08-13 — — US disclosed
EP-0397040-A2 N-heteroaryl-4-quinolinamines, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1990-11-14 — — EP disclosed
US-4970218-A ANALGESIC, ANTIDEPRESSANT, MEMORY ENHANCEMENT HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1990-11-13 — — US disclosed
US-4916135-A ANALGESICS, ALZHEIMER*S HOECHST ROUSSEL PHARMACEUTICALS INC. (US) 1990-04-10 — — US disclosed
US-4880822-A COGNITION ACTIVATORS, ANALGESICS HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-11-14 — — US disclosed
US-3723461-A 2-AMINOMETHYL-3-HALOPLENYLINDOLES SUMITOMO CHEMICAL CO 1973-03-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230312481-A1 SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF NSD3, PML, NSD1 AHR 96/4885ALDH1A1 3447/4885HSD17B10 2340/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.