Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975501 | 0.94 | LMNA (0.54) | LMNAHSP90AB1POLBMAPTTDP1 | |
| SCHEMBL4977885 | 0.93 | LMNA (0.48) | LMNAHSP90AB1POLBMAPTTDP1 | |
| SCHEMBL4976885 | 0.86 | LMNA (0.57) | LMNAHSP90AB1POLBMAPTTDP1 | |
| SCHEMBL4980324 | 0.83 | LMNA (0.50) | LMNAHSP90AB1POLBMAPTTDP1 | |
| SCHEMBL4978686 | 0.82 | LMNA (0.64) | LMNAHSP90AB1POLBMAPTTDP1 | |
| SCHEMBL4979105 | 0.82 | HSP90AB1 (0.62) | LMNAHSP90AB1POLBMAPTTDP1 | |
| SCHEMBL4978720 | 0.82 | LMNA (0.53) | LMNAHSP90AB1POLBMAPTTDP1 | |
| SCHEMBL4980368 | 0.81 | MEN1 (0.46) | LMNAHSP90AB1POLBMAPTTP53 | |
| SCHEMBL4978255 | 0.81 | TRPV6 (0.53) | LMNAHSP90AB1POLBMAPTTDP1 | |
| SCHEMBL4977730 | 0.80 | PIK3CA (0.41) | LMNAHRH3PIK3CAMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | LMNA 4534/4885HSP90AB1 2652/4885POLB 1658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.