Talipexole

Talipexole

SCHEMBL49817

C=CCN1CCc2nc(N)sc2CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 8/20 1.00
DRD3 P35462 7/20 1.00
MAPT P10636 2/20 1.00
ADRA2A P08913 2/20 1.00
ADRA2B P18089 2/20 1.00
ADRA2C P18825 2/20 1.00
HTR2A P28223 2/20 1.00
ADRA1A P35348 2/20 1.00
HRH1 P35367 2/20 1.00
LMNA P02545 1/20 1.00
OPRK1 P41145 1/20 1.00
HRH3 Q9Y5N1 1/20 1.00
RAD52 P43351 2/20 0.97
KDM4E B2RXH2 1/20 0.97
ALDH1A1 P00352 1/20 0.97
RECQL P46063 1/20 0.55
APOBEC3A P31941 1/20 0.46
APOBEC3G Q9HC16 1/20 0.46
KCNH2 Q12809 1/20 0.35
HRH2 P25021 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Talipexole SCHEMBL5605621 1.00 DRD2 (1.00) DRD2DRD3MAPTADRA2AADRA2B
Talipexole SCHEMBL385161 0.98 MAPT (1.00) DRD2DRD3MAPTADRA2AADRA2B
Talipexole SCHEMBL18203528 0.98 MAPT (1.00) DRD2DRD3MAPTADRA2AADRA2B
Talipexole SCHEMBL423325 0.98 MAPT (1.00) DRD2DRD3MAPTADRA2AADRA2B
Talipexole SCHEMBL678761 0.97 DRD2 (0.94) DRD2DRD3MAPTADRA2AADRA2B
SCHEMBL563307 0.79 RAD52 (0.79) DRD2DRD3MAPTADRA2AADRA2B
Hydrochloric Acid SCHEMBL10652670 0.78 RAD52 (0.77) DRD2DRD3MAPTADRA2AADRA2B
SCHEMBL7292466 0.76 DRD2 (0.60) DRD2DRD3MAPTADRA2AADRA2B
SCHEMBL7294700 0.76 LMNA (0.60) DRD2DRD3MAPTADRA2AADRA2B
SCHEMBL7285804 0.76 LMNA (0.60) DRD2DRD3MAPTADRA2AADRA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3445 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4704839-A2 IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF ALPHERABIO LLC (US) 2026-03-11 EP claimed
US-12521398-B2 Composition for treating synucleinopathies STANDIGM INC. (KR) 2026-01-13 US claimed
EP-4673215-A1 GBA1 AND GCS DUAL MODULATOR ONO Pharmaceutical Co., Ltd. (JP) 2026-01-07 EP claimed
US-20250213593-A1 Use of Derivatives based on Sarsasapogenin Structure and Pharmaceutical Compositions thereof BEIJING PHYTOVENT PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) 2025-07-03 US claimed
US-20250186415-A1 EXTENDED-RELEASE PHARMACEUTICAL COMPOSITIONS FOR TREATING EYE CONDITIONS FIFTH THIRD BANK, NATIONAL ASSOCIATION, AS AGENT 2025-06-12 US claimed
EP-4558622-A1 METHODS AND COMPOSITIONS FOR GENERATING HUMAN MIDBRAIN DOPAMINERGIC NEURONS FROM NEURAL PROGENITOR CELLS Trailhead Biosystems Inc. (US) 2025-05-28 EP claimed
CN-120051560-A Methods and compositions for generating human midbrain dopaminergic neurons from neural progenitor cells 特雷尔赫德生物系统股份有限公司 2025-05-27 CN claimed
WO-2025080559-A1 METHODS AND COMPOSITIONS FOR TREATING DRUG OVERDOSE ENALARE THERAPEUTICS INC. (US) 2025-04-17 WO claimed
US-20250114370-A1 METHODS AND COMPOSITIONS FOR TREATING DRUG OVERDOSE ENALARE THERAPEUTICS INC (US) 2025-04-10 US claimed
EP-4489858-A1 EXTENDED-RELEASE PHARMACEUTICAL COMPOSITIONS FOR TREATING EYE CONDITIONS Harrow IP, LLC (US) 2025-01-15 EP claimed
US-4826686-A TRANSDERMAL PATCH FOR SUSTAINED RELEASE OF HYPOTENSIVE AGENT BOEHRINGER INGELHEIM KG (DE) 1989-05-02 US claimed
US-4783456-A A-ADRENERGIC BLOCKING AGENTS RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (US) 1988-11-08 US claimed
EP-0005732-B1 Use of 2-amino-oxazolo- or 2-amino-thiazolo-[5,4-d]azepines and acid-addition salts thereof for the manufacture of a medicament for the treatment of Angina Pectoris Dr. Karl Thomae GmbH (DE) 1988-06-15 EP claimed
US-4707475-A 2-AMINO-6-ALLYL-5,6,7,8-TETRAHYDRO-4H-THIAZOLO(5,4-D)AZEPINE BOEHRINGER INGELHEIM KG (DE) 1987-11-17 US claimed
EP-0227988-A2 Therapeutic system BOEHRINGER INGELHEIM KG (DE) 1987-07-08 EP claimed
US-4645770-A Agent for treating Parkinson's disease or Parkinsonism BOEHRINGER INGELHEIM KG (DE) 1987-02-24 US claimed
EP-0195888-A2 Use of 2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo[5,4-d]azepin in the reduction of prolactin serum levels BOEHRINGER INGELHEIM KG (DE) 1986-10-01 EP claimed
EP-0192098-A2 Use of 2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin for the preparation of a medicament for the treatment of Parkinson's disease, or of parkinsonism BOEHRINGER INGELHEIM KG (DE) 1986-08-27 EP claimed
US-4400378-A THIAZOLO OR OXAZOLO COMPOUNDS KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1983-08-23 US claimed
US-4259342-A HYPOTENSIVE, SEDATIVE, ANTITUSSIVE, ANTIINFLAMMATORY BOEHRINGER INGELHEIM GMBH (DE) 1981-03-31 US claimed