Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4981108 | 0.91 | KMT2A (0.58) | SIGMAR1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4980641 | 0.85 | MCHR1 (0.63) | SIGMAR1ALDH1A1NPC1RAB9AMCHR1 | |
| SCHEMBL4980231 | 0.82 | RAB9A (0.74) | SIGMAR1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4979498 | 0.81 | ALDH1A1 (0.63) | SIGMAR1RXFP1ALDH1A1NPC1RAB9A | |
| SCHEMBL4977767 | 0.81 | MCHR1 (0.65) | SIGMAR1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4983996 | 0.80 | RAB9A (0.56) | SIGMAR1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4981461 | 0.80 | MCHR1 (0.52) | SIGMAR1ALDH1A1THRBNPC1MCHR1 | |
| SCHEMBL5463995 | 0.79 | NPC1 (0.56) | RXFP1ALDH1A1THRBNPC1POLB | |
| SCHEMBL13647189 | 0.76 | HSD17B10 (0.56) | ALDH1A1SHMT2MEN1KMT2A | |
| SCHEMBL4981608 | 0.75 | SMN1; SMN2 (0.57) | ALDH1A1NPC1RAB9ASMN1; SMN2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | US | disclosed |
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | US | disclosed |
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | HRH3, HRH1, HRH4 | SIGMAR1 93/4885RXFP1 155/4885ALDH1A1 451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.