Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | STS | P08842 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985082 | 0.89 | NR1H4 (0.49) | KCNH2NR1H4LMNAPTGESALOX5 | |
| Hydrochloric Acid SCHEMBL4985557 | 0.87 | NR1H4 (0.48) | KCNH2NR1H4LMNAPTGESALOX5 | |
| SCHEMBL4981172 | 0.86 | NR1H4 (0.40) | NR1H4 | |
| Hydrochloric Acid SCHEMBL4981490 | 0.85 | NR1H4 (0.39) | NR1H4 | |
| SCHEMBL8802180 | 0.85 | ESR1 (0.49) | LMNA | |
| SCHEMBL4979785 | 0.84 | TNNC1 (0.41) | LMNASTS | |
| SCHEMBL4980138 | 0.82 | NR1H4 (0.44) | KCNH2NR1H4LMNAPTGESALOX5 | |
| SCHEMBL4994487 | 0.82 | NR1H4 (0.52) | KCNH2NR1H4LMNAPTGESALOX5 | |
| Hydrochloric Acid SCHEMBL4985726 | 0.81 | NR1H4 (0.43) | KCNH2NR1H4LMNAPTGESALOX5 | |
| SCHEMBL4981466 | 0.80 | NR1H4 (0.43) | NR1H4PTGESALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351743-B1 | Therapeutic guanidines | WYETH (US) | 2008-04-01 | — | — | US | claimed |