Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | BCL9 | O00512 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979394 | 0.94 | PTGER1 (0.40) | KDM4EFFAR4MTNR1AMTNR1BLMNA | |
| SCHEMBL4267805 | 0.93 | KDM4E (0.48) | KDM4EFFAR4MTNR1AMTNR1BLMNA | |
| SCHEMBL3974854 | 0.91 | KDM4E (0.49) | KDM4EFFAR4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4982625 | 0.91 | KDM4E (0.42) | KDM4EFFAR4MTNR1AMTNR1BLMNA | |
| SCHEMBL4982648 | 0.91 | FABP4 (0.41) | KDM4EFFAR4LTB4RMTNR1AMTNR1B | |
| SCHEMBL3984320 | 0.90 | PTGDR2 (0.42) | KDM4EFFAR4LTB4RMTNR1AMTNR1B | |
| SCHEMBL4980205 | 0.90 | L3MBTL1 (0.43) | KDM4EFFAR4LTB4RMTNR1AMTNR1B | |
| SCHEMBL3980259 | 0.89 | KDM4E (0.46) | KDM4EFFAR4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL3974991 | 0.87 | KDM4E (0.44) | KDM4EMTNR1AMTNR1BSIRT2SMN1; SMN2 | |
| SCHEMBL4980626 | 0.86 | KDM4E (0.42) | KDM4EMTNR1AMTNR1BLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113975-A1 | THIOUREA COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-05-15 | — | — | US | disclosed |
| US-20080096875-A1 | THIOUREA COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096875-A1 | THIOUREA COMPOUNDS | TPMT, HAVCR2, ETV6 | KDM4E 1989/4885FFAR4 3904/4885LTB4R 2744/4885 |
| US-20080113975-A1 | THIOUREA COMPOUNDS | TPMT, HAVCR2, EIF2AK2 | KDM4E 2103/4885FFAR4 4050/4885LTB4R 2958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.