Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.54 |
| ▸ | MAOB | P27338 | 6/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497577 | 0.94 | NR1H4 (0.60) | NR1H4MAOBMAOAKMT2AALDH1A1 | |
| SCHEMBL498015 | 0.86 | NR1H4 (0.51) | NR1H4KMT2ARAB9ADHODHL3MBTL1 | |
| SCHEMBL3150919 | 0.85 | NR1H4 (0.61) | NR1H4 | |
| SCHEMBL3150227 | 0.81 | NR1H4 (0.59) | NR1H4RAB9A | |
| SCHEMBL3149677 | 0.81 | NR1H4 (0.63) | NR1H4 | |
| SCHEMBL498233 | 0.81 | NR1H4 (0.62) | NR1H4MAOBMAOAALDH1A1MAPT | |
| SCHEMBL3164115 | 0.81 | NR1H4 (0.79) | NR1H4KMT2A | |
| SCHEMBL3164111 | 0.81 | NR1H4 (0.79) | NR1H4KMT2A | |
| SCHEMBL498760 | 0.80 | NR1H4 (0.58) | NR1H4 | |
| SCHEMBL498759 | 0.79 | NR1H4 (0.57) | NR1H4MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106077-B2 | Compounds and methods for modulating FXR | ELI LILLY AND COMPANY (US) | 2012-01-31 | — | — | US | disclosed |
| EP-2029558-B1 | COMPOUNDS AND METHODS FOR MODULATING FXR | LILLY CO ELI (US) | 2010-03-10 | — | — | EP | disclosed |