Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4989496 | 0.84 | TSHR (0.34) | TSHRP2RX7KMT2AMEN1ALDH1A1 | |
| SCHEMBL4982810 | 0.79 | P2RX7 (0.47) | TSHRP2RX7KMT2AMEN1USP2 | |
| SCHEMBL4988202 | 0.78 | EPHX2 (0.46) | TSHREPHX2P2RX7KMT2AMEN1 | |
| SCHEMBL4983686 | 0.78 | TSHR (0.44) | TSHREPHX2P2RX7KMT2AMEN1 | |
| SCHEMBL4985109 | 0.77 | P2RX7 (0.49) | TSHRP2RX7KMT2AMEN1USP2 | |
| SCHEMBL4988059 | 0.76 | P2RX7 (0.41) | TSHREPHX2P2RX7KMT2AMEN1 | |
| SCHEMBL4993385 | 0.76 | P2RX7 (0.41) | TSHREPHX2P2RX7KMT2AMEN1 | |
| SCHEMBL4985993 | 0.76 | P2RX7 (0.48) | TSHREPHX2P2RX7KMT2AMEN1 | |
| SCHEMBL4983666 | 0.76 | P2RX7 (0.40) | TSHREPHX2P2RX7KMT2AMEN1 | |
| SCHEMBL4985280 | 0.76 | P2RX7 (0.43) | TSHREPHX2P2RX7KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | TSHR 3850/4885EPHX2 569/4885P2RX7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.