Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.56 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.56 |
| ▸ | ITGAL | P20701 | 1/20 | 0.56 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | CA3 | P07451 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TYR | P14679 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | DPP4 | P27487 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985018 | 1.00 | PLA2G4A (0.60) | PLA2G4ACYP1A2ITGB2ICAM1ITGAL | |
| SCHEMBL126171 | 0.89 | CYP1A2 (0.72) | CYP1A2ITGB2ICAM1ITGALHCAR2 | |
| SCHEMBL269140 | 0.89 | CYP1A2 (0.72) | CYP1A2ITGB2ICAM1ITGALHCAR2 | |
| SCHEMBL4732055 | 0.89 | CYP1A2 (0.72) | CYP1A2ITGB2ICAM1ITGALHCAR2 | |
| Hydrochloric Acid SCHEMBL5929339 | 0.87 | CYP1A2 (0.69) | CYP1A2ITGB2ICAM1ITGALHCAR2 | |
| SCHEMBL11452510 | 0.87 | CYP1A2 (0.69) | CYP1A2ITGB2ICAM1ITGALHCAR2 | |
| Hydrochloric Acid SCHEMBL27093050 | 0.87 | CYP1A2 (0.69) | CYP1A2ITGB2ICAM1ITGALHCAR2 | |
| SCHEMBL2774769 | 0.85 | HDAC3 (0.67) | PLA2G4ACYP1A2HCAR2CA12AKR1B10 | |
| SCHEMBL2774772 | 0.85 | HDAC3 (0.67) | PLA2G4ACYP1A2HCAR2CA12AKR1B10 | |
| Methyl Alcohol SCHEMBL27319502 | 0.85 | CYP1A2 (0.67) | CYP1A2ITGB2ICAM1ITGALHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348433-B2 | Quinolinones as prostaglandin receptor ligands | MERCK FROSST CANADA & CO. (CA) | 2008-03-25 | — | — | US | disclosed |
| EP-1458718-B1 | QUINOLINONES AS PROSTAGLANDIN RECEPTOR LIGANDS | MERCK FROSST CANADA LTD (CA) | 2006-10-25 | — | — | EP | disclosed |
| US-20050222194-A1 | Quinolinones as prostaglandin receptor ligands | MERCK FROSST CANADA LTD. (CA) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222194-A1 | Quinolinones as prostaglandin receptor ligands | PTGFR, PTGER1, PTGER2 | PLA2G4A 56/4885CYP1A2 251/4885ITGB2 1290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.