Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.67 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.67 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.67 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.67 |
| ▸ | TNKS | O95271 | 1/20 | 0.67 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 2/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2774769 | 1.00 | HDAC3 (0.67) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL4985018 | 0.85 | PLA2G4A (0.60) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL4985013 | 0.85 | PLA2G4A (0.60) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL7926019 | 0.85 | FOS (0.54) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL28657869 | 0.84 | CYP1B1 (0.70) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Diphenylsulfane SCHEMBL29264708 | 0.83 | ALDH1A1 (0.54) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL1431255 | 0.82 | HCAR2 (0.63) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL1431257 | 0.82 | HCAR2 (0.63) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL10747781 | 0.81 | HDAC1 (0.91) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL10747790 | 0.81 | HDAC1 (0.91) | HDAC3HDAC4HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140045800-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-02-13 | — | — | US | disclosed |
| US-8372823-B2 | Tetracyclic inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2152082-B1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | SCRIPPS RESEARCH INST (US) | 2012-08-29 | — | — | EP | disclosed |
| US-20100249078-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPS RESEARCH INSTITUTE (US) | 2010-09-30 | — | — | US | disclosed |
| EP-2152082-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | The Scripps Research Institute (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008147553-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249078-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, APEH | HDAC3 55/4885HDAC4 78/4885HDAC1 81/4885 |
| US-20140045800-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, APEH | HDAC3 55/4885HDAC4 78/4885HDAC1 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.