Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023588 | 0.79 | DPP7 (0.67) | SIGMAR1DPP7CHRM2CCR3KMT2A | |
| SCHEMBL13621157 | 0.78 | SIGMAR1 (0.66) | SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL14417946 | 0.75 | KDM4E (0.72) | KDM4EALDH1A1TSHRPOLB | |
| SCHEMBL2056150 | 0.75 | MC4R (0.66) | KDM4EALDH1A1 | |
| SCHEMBL16026613 | 0.74 | DPP7 (0.81) | SIGMAR1DPP7USP30CCR3KDM4E | |
| SCHEMBL8144850 | 0.74 | HRH3 (0.71) | HSD11B1KDM4EALDH1A1TSHRMEN1 | |
| SCHEMBL27759916 | 0.74 | KDM4E (0.62) | HSD11B1KDM4EALDH1A1TSHRMEN1 | |
| SCHEMBL648348 | 0.73 | SIGMAR1 (0.60) | SIGMAR1CHRM2CHRM1CHRM3MEN1 | |
| SCHEMBL4975754 | 0.72 | EPHX1 (0.53) | SIGMAR1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL10856726 | 0.72 | KDM4E (0.65) | HSD11B1KDM4EALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | US | disclosed |
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | US | disclosed |
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | HRH3, HRH1, HRH4 | SIGMAR1 93/4885DPP7 3310/4885HSD11B1 3558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.