Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.63 |
| ▸ | KDR | P35968 | 11/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 9/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7625312 | 0.87 | ENPP1 (0.46) | ENPP1KDREPHA2EPHB4CHEK1 | |
| SCHEMBL6983690 | 0.87 | ENPP1 (0.46) | ENPP1KDREPHA2EPHB4CHEK1 | |
| SCHEMBL7838826 | 0.81 | KDR (0.49) | ENPP1KDREPHA2EPHB4CHEK1 | |
| SCHEMBL15520007 | 0.79 | ENPP1 (0.56) | ENPP1KDREPHA2EPHB4FLT1 | |
| SCHEMBL1132496 | 0.79 | ENPP1 (0.58) | ENPP1TLR9TLR7PDE3A | |
| SCHEMBL1012358 | 0.78 | ENPP1 (0.79) | ENPP1KDREPHA2EPHB4FLT1 | |
| SCHEMBL1013021 | 0.78 | ENPP1 (0.79) | ENPP1KDREPHA2EPHB4FLT1 | |
| SCHEMBL662795 | 0.78 | ENPP1 (0.79) | ENPP1KDREPHA2EPHB4FLT1 | |
| SCHEMBL7154861 | 0.78 | TLR9 (0.56) | ENPP1TLR9TLR7PDE3A | |
| SCHEMBL6977879 | 0.77 | TRPA1 (0.52) | KDREPHB4FLT1EGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994023-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007099317-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | disclosed |