Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 9/20 | 0.46 |
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | FLT1 | P17948 | 5/20 | 0.46 |
| ▸ | FLT4 | P35916 | 5/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838826 | 0.85 | KDR (0.49) | TRPA1KDREGFRFLT1FLT4 | |
| SCHEMBL4424919 | 0.81 | KDR (0.60) | TRPA1KDREGFRFLT1FLT4 | |
| SCHEMBL4420738 | 0.80 | KDR (0.66) | TRPA1KDREGFRFLT1FLT4 | |
| SCHEMBL5492065 | 0.79 | TRPA1 (0.60) | TRPA1KDREGFRFLT1FLT4 | |
| SCHEMBL4423983 | 0.79 | TRPA1 (0.60) | TRPA1KDREGFRFLT1FLT4 | |
| SCHEMBL4419529 | 0.78 | KDR (0.60) | TRPA1KDREGFRFLT1FLT4 | |
| SCHEMBL4985294 | 0.77 | ENPP1 (0.63) | KDREGFRFLT1FLT4FGFR1 | |
| SCHEMBL6983690 | 0.77 | ENPP1 (0.46) | KDREGFRFLT1FLT4FGFR1 | |
| SCHEMBL7625312 | 0.77 | ENPP1 (0.46) | KDREGFRFLT1FLT4FGFR1 | |
| SCHEMBL4421705 | 0.77 | EGFR (0.55) | TRPA1KDREGFRFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| EP-1218353-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca UK Limited (GB) | 2002-07-03 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |
| WO-2001004102-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |