Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pemetrexed. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS known ✓ | P04818 | 5/20 | 0.69 |
| ▸ | GART known ✓ | P22102 | 10/20 | 0.66 |
| ▸ | DHFR known ✓ | P00374 | 6/20 | 0.66 |
| ▸ | FOLR1 | P15328 | 4/20 | 0.66 |
| ▸ | SLC46A1 | Q96NT5 | 4/20 | 0.66 |
| ▸ | ATIC | P31939 | 3/20 | 0.66 |
| ▸ | FOLR2 | P14207 | 3/20 | 0.66 |
| ▸ | SLC19A1 | P41440 | 3/20 | 0.66 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.66 |
| ▸ | FRK | P42685 | 1/20 | 0.66 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pemetrexed SCHEMBL2268170 | 0.95 | TYMS (0.70) | TYMSGARTDHFRFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL18348 | 0.94 | TYMS (0.78) | TYMSGARTDHFRFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL1651788 | 0.94 | TYMS (0.78) | TYMSGARTDHFRFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL5333210 | 0.94 | TYMS (0.78) | TYMSGARTDHFRFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL2037608 | 0.93 | TYMS (0.77) | TYMSGARTDHFRFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL1934530 | 0.93 | TYMS (0.77) | TYMSGARTDHFRFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL21599244 | 0.93 | TYMS (0.77) | TYMSGARTDHFRFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL135815 | 0.93 | TYMS (0.77) | TYMSGARTDHFRFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL15649196 | 0.92 | TYMS (0.75) | TYMSGARTDHFRFOLR1SLC46A1 | |
| Pemetrexed SCHEMBL2549428 | 0.92 | GART (0.77) | TYMSGARTDHFRFOLR1SLC46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629152-B2 | Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid | SICOR, INC. (US) | 2014-01-14 | — | — | US | disclosed |
| US-20080139810-A1 | Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid | ASSIA CHEMICAL INDUSTRIES LTD. (IL) | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139810-A1 | Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid | DCTD, DPYD, PDCD2L | TYMS 7/4885GART 77/4885DHFR 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.