Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | TP53 | P04637 | 3/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.73 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 7/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL684275 | 0.93 | ALDH1A1 (0.85) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL4886316 | 0.91 | ALDH1A1 (0.81) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL12277843 | 0.91 | ALDH1A1 (0.88) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL18835823 | 0.90 | ALDH1A1 (0.78) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL21550099 | 0.90 | ALDH1A1 (0.78) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL12323362 | 0.90 | ALDH1A1 (0.78) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL12277453 | 0.90 | ALDH1A1 (0.85) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL20854326 | 0.90 | ALDH1A1 (0.85) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL29356945 | 0.90 | ALDH1A1 (0.85) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL12323326 | 0.88 | ALDH1A1 (0.76) | ALDH1A1TP53HIF1ACYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2674145-B1 | Self-etching dental adhesive compositions | BISCO INC (US) | 2022-06-15 | — | — | EP | disclosed |
| US-9527931-B2 | Hydrophobic self-etch dental adhesive compositions | BISCO, INC. (US) | 2016-12-27 | — | — | US | disclosed |
| EP-2674145-A1 | Hydrophobic self-etching dental adhesive compositions | Bisco, Inc. (US) | 2013-12-18 | — | — | EP | disclosed |
| US-20130217800-A1 | Hydrophobic self-etch dental adhesive compositions | BISCO, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-20120046386-A1 | Dental primer adhesive system and optional hydrophobic resin | SUH BYOUNG (US) | 2012-02-23 | — | — | US | disclosed |
| US-8106110-B2 | first portion: bisphenol diglycidylmethacrylate phosphate, 2-hydroxyethylmethacrylate, biphenyl dimethacrylate, dipentaerythritol pentaacrylate, bisphenyl A diglycidylmethacrylate, ethyl-4-dimethyl-aminobenzoate and camphorquinone; second portion: deionized water, aryl sulfinate, thymol blue, and ethanol | BISCO, INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-8026297-B2 | inclusion of hydrophobic polymerizable monomer and multi-functional cross-linking agent improves long term stability or durability of polymerized primer system to the dental restoration and to the tooth, dentin, enamel and other dental surfaces | BISCO, INC. (US) | 2011-09-27 | — | — | US | disclosed |
| EP-2117494-A1 | DENTAL PRIMER ADHESIVE SYSTEM AND OPTIONAL HYDROPHOBIC RESIN | Bisco, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| EP-2114357-A1 | DUAL APPLICATION MODE SELF-ETCH DENTAL ADHESIVES COMPATIBLE WITH SELF-CURED AND DUAL-CURED COMPOSITES | Bisco, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008094925-A1 | DENTAL PRIMER ADHESIVE SYSTEM AND OPTIONAL HYDROPHOBIC RESIN | BISCO, INC. (US) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008094923-A1 | DUAL APPLICATION MODE SELF-ETCH DENTAL ADHESIVES COMPATIBLE WITH SELF-CURED AND DUAL-CURED COMPOSITES | BISCO, INC. (US) | 2008-08-07 | — | — | WO | disclosed |
| US-20080182922-A1 | Dual Application Mode Self-Etch Dental Adhesives Compatible with Self-Cured and Dual-Cured Composites | BISCO, INC. (US) | 2008-07-31 | — | — | US | disclosed |
| US-20080182921-A1 | Dental Primer Adhesive System and Optional Hydrophobic Resin | BISCO, INC. (US) | 2008-07-31 | — | — | US | disclosed |
| US-5749733-A | DENTAL | BISCO, INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5658963-A | HYDROPHILIC MONOMERS, REACTIVE DILUENT MONOMERS, HIGH VISCOSITY ADHESION RESIN, PHOTOINITIATOR AND SOLVENTS, USEFUL FOR ONE-STEP APPLICATION FOR PRIMING AND IMPARTING ENHANCED ADHESION BETWEEN SUBSTRATE AND DENTAL RESTORATIVES | BISCO, INC. (US) | 1997-08-19 | — | — | US | disclosed |