Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 8/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2454503 | 0.86 | CYP1A2 (1.00) | CYP2D6CYP1A2MAPTKMT2AKIF11 | |
| SCHEMBL2454501 | 0.86 | CYP1A2 (1.00) | CYP2D6CYP1A2MAPTKMT2AKIF11 | |
| SCHEMBL838044 | 0.80 | CYP2D6 (0.54) | CYP2D6CYP1A2MAPTKMT2AKIF11 | |
| SCHEMBL838052 | 0.80 | CYP2D6 (0.54) | CYP2D6CYP1A2MAPTKMT2AKIF11 | |
| SCHEMBL4886581 | 0.80 | CYP2D6 (0.54) | CYP2D6CYP1A2MAPTKMT2AKIF11 | |
| SCHEMBL17513527 | 0.80 | CYP1A2 (0.53) | CYP2D6CYP1A2MAPTKMT2AKIF11 | |
| SCHEMBL75956 | 0.79 | CYP1A2 (0.68) | CYP2D6CYP1A2MAPTKMT2AKIF11 | |
| SCHEMBL28636479 | 0.79 | CYP2D6 (0.68) | CYP2D6CYP1A2MAPTKMT2AKIF11 | |
| SCHEMBL20681289 | 0.78 | MAPT (0.61) | CYP2D6CYP1A2MAPTKMT2AKIF11 | |
| SCHEMBL27570861 | 0.78 | CYP1A2 (0.78) | CYP2D6CYP1A2MAPTKMT2AKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393958-B2 | Triamide-substituted heterobicyclic compounds | PFIZER, INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-7368573-B2 | Triamide-substituted heterobicyclic compounds | PFIZER INC. (US) | 2008-05-06 | — | — | US | disclosed |
| US-20070093525-A1 | Triamide-substituted heterobicyclic compounds | PFIZER INC | 2007-04-26 | — | — | US | disclosed |
| US-20060223851-A1 | TRIAMIDE-SUBSTITUTED HETEROBICYCLIC COMPOUNDS | BERTINATO PETER | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223851-A1 | TRIAMIDE-SUBSTITUTED HETEROBICYCLIC COMPOUNDS | APOB, MTPN, CTRB1 | CYP2D6 689/4885CYP1A2 528/4885MAPT 3215/4885 |
| US-20070093525-A1 | Triamide-substituted heterobicyclic compounds | APOB, MTPN, CTRB1 | CYP2D6 689/4885CYP1A2 528/4885MAPT 3215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.