Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL1052753 | 0.70 | ALDH1A1 (0.36) | ALDH1A1MAPTPTGS1SLC7A5 | |
| SCHEMBL12141691 | 0.69 | ALDH1A1 (0.38) | ALDH1A1TSHR | |
| SCHEMBL262225 | 0.67 | GAA (0.46) | ALDH1A1TSHR | |
| SCHEMBL27709697 | 0.67 | TSHR (0.35) | ALDH1A1TSHR | |
| SCHEMBL10643900 | 0.67 | ALDH1A1 (0.33) | ALDH1A1MAPTPTGS1SLC7A5 | |
| SCHEMBL11428292 | 0.65 | ALDH1A1 (0.35) | ALDH1A1MAPTPTGS1TSHR | |
| Pivalate SCHEMBL4319755 | 0.64 | FFAR3 (0.39) | ALDH1A1MAPTPTGS1SLC7A5TSHR | |
| SCHEMBL28515563 | 0.64 | TSHR (0.35) | TSHR | |
| SCHEMBL23120329 | 0.63 | — | — | |
| Acetic Acid SCHEMBL28627040 | 0.63 | FFAR3 (0.44) | SLC7A5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070789-A1 | PROCESS FOR MAKING AMLODIPINE, DERIVATIVES THEREOF, AND PRECURSORS THEREFOR | SLANINA PAVEL | 2008-03-20 | — | — | US | disclosed |
| US-20060167265-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | PETERS THEODORUS H | 2006-07-27 | — | — | US | disclosed |
| US-20050137405-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | PETERS THEODORUS H A (NL) | 2005-06-23 | — | — | US | disclosed |
| US-6858738-B2 | Process for making amlodipine, derivatives thereof, and precursors therefor | SYNTHON BV (NL) | 2005-02-22 | — | — | US | disclosed |
| US-20030220501-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | SYNTHON IP INC. | 2003-11-27 | — | — | US | disclosed |
| US-6653481-B2 | Used as calcium channel blockers | SYNTHON BV (NL) | 2003-11-25 | — | — | US | disclosed |
| EP-1345901-A2 | PROCESS FOR MAKING AMLODIPINE, DERIVATIVES THEREOF, AND PRECURSORS THEREFOR | Bioorganics B.V. (NL) | 2003-09-24 | — | — | EP | disclosed |
| US-20020143046-A1 | Process for making amlodipine, derivatives therof, and precursors therefor | SYNTHON IP INC. | 2002-10-03 | — | — | US | disclosed |
| WO-2002053535-A2 | PROCESS FOR MAKING AMLODIPINE, DERIVATIVES THEREOF, AND PRECURSORS THEREFOR | BIOORGANICS B.V. (NL) | 2002-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167265-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | CYP4A11, CYP4F11, CACNA1D | ALDH1A1 1591/4885MAPT 957/4885PTGS1 2095/4885 |
| US-20050137405-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | CACNA1D, CACNA1S, CACNA1C | ALDH1A1 1269/4885MAPT 3435/4885PTGS1 389/4885 |
| US-20030220501-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | CACNA1D, CACNA1S, CACNA1C | ALDH1A1 677/4885MAPT 3498/4885PTGS1 332/4885 |
| US-20020143046-A1 | Process for making amlodipine, derivatives therof, and precursors therefor | CACNA1D, CACNA1F, CACNA1S | ALDH1A1 1332/4885MAPT 2410/4885PTGS1 565/4885 |
| US-20080070789-A1 | PROCESS FOR MAKING AMLODIPINE, DERIVATIVES THEREOF, AND PRECURSORS THEREFOR | CACNA1D, CACNA1F, CYP51A1 | ALDH1A1 908/4885MAPT 2593/4885PTGS1 882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.