Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 11/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.44 |
| ▸ | HTR1B | P28222 | 7/20 | 0.44 |
| ▸ | HTR1D | P28221 | 7/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4994047 | 0.91 | ADRA1A (0.44) | ADRA1AADRA1DADRA1BADRA2AHTR1B | |
| SCHEMBL4989442 | 0.88 | ADRA1A (0.42) | ADRA1AADRA1DADRA1BADRA2AHTR1B | |
| SCHEMBL4994677 | 0.88 | ADRA1A (0.47) | ADRA1AADRA1DADRA1BADRA2AHTR1B | |
| SCHEMBL4989505 | 0.84 | ADRA1A (0.47) | ADRA1AADRA1DADRA1BADRA2AHTR1B | |
| SCHEMBL4986567 | 0.81 | ADRA1A (0.47) | ADRA1AADRA1DADRA1BADRA2AHTR1B | |
| SCHEMBL4989586 | 0.81 | ADRA1A (0.42) | ADRA1AADRA1DADRA1BADRA2AHTR1B | |
| SCHEMBL4994698 | 0.81 | HTR1B (0.51) | ADRA1AADRA1DADRA1BADRA2AHTR1B | |
| SCHEMBL5200788 | 0.81 | HTR1B (0.51) | ADRA1AADRA1DADRA1BADRA2AHTR1B | |
| SCHEMBL4993343 | 0.80 | HTR1B (0.44) | ADRA1AADRA1DADRA1BADRA2AHTR1B | |
| Hydrochloric Acid SCHEMBL5201882 | 0.80 | HTR1B (0.50) | ADRA1AADRA1DADRA1BADRA2AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756395-B2 | CYCLIZATION OF N-(4-CYANOMETHYLPHENYL)METHANESULFONAMIDES WITH ETHYLENEDIAMINE TO FORM N-(4-IMIDAZOL-2-YLMETHYL)-PHENYL) -METHANESULFONAMIDES; INCONTINENCE, SEXUAL DYSFUNCTION, NASAL CONGESTION, AND CNS DISORDERS; ALPHA 1 ADRENERGIC AGONISTS | ROCHE PALO ALTO LLC | 2004-06-29 | — | — | US | claimed |
| US-7407980-B2 | Imidazolinylmethyl aralkylsulfonamides | ROCHE PALO ALTO LLC (US) | 2008-08-05 | — | — | US | disclosed |
| US-7407980-B2 | Imidazolinylmethyl aralkylsulfonamides | ROCHE PALO ALTO LLC (US) | 2008-08-05 | — | — | US | disclosed |
| US-7407980-B2 | Imidazolinylmethyl aralkylsulfonamides | ROCHE PALO ALTO LLC (US) | 2008-08-05 | — | — | US | disclosed |